Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20180031
Brazilian Journal of Pain
Artigo de Revisão

Does pregabalin improve sleep disorders in fibromyalgia?

A pregabalina melhora os distúrbios do sono na fibromialgia?

Rodrigo Lorenzi Poluha; Eduardo Grossmann

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Abstract

BACKGROUND AND OBJECTIVES: Fibromyalgia is a chronic generalized pain syndrome accompanied by somatic symptoms, mainly represented by sleep disorders. Pregabalin is the main agent among pharmacological treatments.

CONTENTS: An electronic search was performed in the databases Lilacs, Pubmed/Medline, Scielo and ScienceDirect. The keywords used in English and Portuguese were “fibromyalgia”; “sleep disorder”, “treatment”; “pregabalin”; “medicine”; “fibromialgia”; “distúrbios do sono”, “tratamento”; “pregabalina”; “fármacos”. Only articles of literature review, systematic review, meta-analysis and randomized clinical studies published between October 1992 and May 2018 were included.

CONCLUSION: Pregabalin is efficient and safe in the management of sleep disorders in patients with fibromyalgia because it reduces the number of awakenings and increases sleep duration.

Keywords

Fibromyalgia, Pregabalin, Sleep wake disorders

Resumo

JUSTIFICATIVA E OBJETIVOS: A fibromialgia é uma síndrome de dor generalizada crônica, acompanhada de sintomas somáticos, representados principalmente por distúrbios do sono. Dentre os tratamentos farmacológicos, a pregabalina é o principal representante.

CONTEÚDO: Foi realizada uma busca eletrônica nas bases de dados Lilacs, Pubmed/Medline, Scielo e ScienceDirect, cruzando-se os seguintes descritores em língua inglesa e portuguesa: “fibromyalgia”; “sleep disorder”, “treatment”; “pregabalin”; “medicine”; “fibromialgia”; “distúrbios do sono”, “tratamento”; “pregabalina”; “fármacos”. Foram incluídos somente artigos de revisão de literatura, revisão sistemática, meta-análise e estudos clínicos randomizados publicados no período de outubro de 1992 a maio de 2018.

CONCLUSÃO: A pregabalina é eficiente e segura no manuseio dos distúrbios do sono em pacientes com fibromialgia, pois diminui o número de despertares e aumenta o tempo de duração do sono.

Palavras-chave

Fibromialgia, Pregabalina, Transtornos do sono-vigília

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Submetido em:
10/04/2018

Aceito em:
08/04/2018

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