Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20180039
Brazilian Journal of Pain
Original Article

Evaluation of cognitive impairment in patients with episodic migraine

Avaliação do comprometimento cognitivo em pacientes com migrânea episódica

Caroliny Trevisan Teixeira; Carolina Minarro Cremasco; Anelise Melo; Carolina Cáfaro; Marcelo Cedrinho Ciciarelli; Karen dos Santos Ferreira

http://dx.doi.org/10.5935/2595-0118.20180039 BrJP, vol.1, n3, p.197-201, 2018
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Abstract

BACKGROUND AND OBJECTIVES: The purpose of this study was to evaluate the presence of cognitive deficits in patients with episodic migraine and control group, and to compare with the results previously described in the literature.

METHODS: Patients with episodic migraine were included according to the International Headache Society criteria, and a control group was selected, matched by sex, age, and schooling. Patients were asked about the frequency and intensity of headaches, medications used, and comorbidities. Afterwards, a neuropsychological assessment was applied using the Montreal Cognitive Assessment, the clock drawing test, the verbal fluency test, and the Stroop test. The main variables influencing cognitive dysfunctions were analyzed (depressive disorder, anxiety disorder, sleep disorder, use of medication).

RESULTS: Thirty patients with episodic migraine and 30 controls were evaluated. Patients with episodic migraine had a performance in the Montreal Cognitive Assessment test (p=0.53), the clock drawing test (p=0.80), the verbal fluency test (p=0.44) and the Stroop test (p=0.97) similar to the control group. Patients with chronic migraine (30 patients and 30 controls) performed a Montreal Cognitive Assessment test (p=0.00), verbal fluency test (p=0.00) and Stroop test (p=0.00) lower than the group control. The main variables influencing cognitive disorders were studied by linear regression, and none of these variables was an influencing factor in the Montreal Cognitive Assessment test.

CONCLUSION: Patients with episodic migraine did not present cognitive deficits compared to a control group.

Keywords

Cognitive dysfunctions, Headache, Migraine

Resumo

JUSTIFICATIVA E OBJETIVOS: A proposta deste estudo foi avaliar a presença de déficits cognitivos em pacientes com migrânea episódica e grupo controle, e comparar com os resultados previamente descritos na literatura.

MÉTODOS: Foram incluídos pacientes com migrânea episódica, segundo os critérios da International Headache Society, e selecionado um grupo controle pareado por sexo, idade e escolaridade. Os pacientes foram questionados sobre a frequência e intensidade de crises, fármacos, comorbidades. Posteriormente, foi realizada a avaliação neuropsicológica através do Montreal Cognitive Assessment, do teste do relógio, teste da fluência verbal e Stroop teste. As principais variáveis influenciadoras de distúrbios cognitivos foram analisadas (transtorno depressivo, transtorno de ansiedade, distúrbios do sono, uso de fármacos).

RESULTADOS: Foram avaliados 30 pacientes com migrânea episódica e 30 controles. Os pacientes com migrânea episódica apresentaram uma performance no Montreal Cognitive Assessment teste (p=0,53), teste do relógio (p=0,80), teste da fluência verbal (p=0,44) e Stroop teste (p=0,97) semelhante ao grupo controle. Pacientes com enxaqueca crônica (30 pacientes e 30 controles) realizaram um teste de Montreal Cognitive Assessment teste (p=0,00), teste de fluência verbal (p=0,00) e teste de Stroop (p=0,00) menor que o grupo controle. As principais variáveis influenciadoras de distúrbios cognitivos foram estudadas através de regressão linear e nenhuma dessas variáveis apresentou-se como fator de influência no Montreal Cognitive Assessment.

CONCLUSÃO: Os pacientes com migrânea episódica não apresentaram déficits cognitivos em comparação com um grupo controle.

Palavras-chave

Cefaleia, Disfunção cognitiva, Migrânea

References

Rasmussen BK. Epidemiology of headache. Cephalalgia. 2001;21(7):774-7.

Becker WJ, Gladstone JP, Aube M. Migraine prevalence, diagnosis, and disability. Can J Neurol Sci. 2007;34(4):3-9.

Speciali JG, Silva WF. Cefaléias. 2002.

The International Classification of Headache Disorders: 3rd ed. Cephalalgia. 2013;33(^sSuppl 9):644-58.

Giazomozzi AR, Vindas AP, Silva Jr AA, Bordini CA, Buonanotte CF, Roesler CA. Latin American consensus on guidelines for chronic migraine treatment. Arq Neuropsiquiatr. 2013;71(7):478-86.

Berryman C, Stanton TR, Bowering K Jane, Tabor A, McFarlane A, Moseley G Lorimer. Evidence for working memory deficits in chronic pain: a systematic review and meta-analysis. Pain. 2013;154(8):1181-96.

McKendrick AM, Badcock DR, Badcock JC, Gurgone M. Motion perception in migraineurs: abnormalities are not related to attention. Cephalalgia. 2006;26(9):1131-6.

Leijdekkers ML, Passchier J, Goudswaard P, Menges LJ, Orlebeke JF. Migraine patients cognitively impaired?. Headache. 1990;30(6):352-8.

Gaist D, Pedersen L, Madsen C, Tsiropoulos I, Bak S, Sindrup S. Long-term effects of migraine on cognitive function: a population-based study of Danish twins. Neurology. 2005;64(4):600-7.

Jelicic M, Boxtel MP van, Houx PJ, Jolles J. Does migraine headache affect cognitive function in the elderly? Report from the Maastricht Aging Study (MAAS). Headache. 2000;40(9):715-9.

Pearson AJ, Chronicle EP, Maylor EA, Bruce LA. Cognitive function is not impaired in people with a long history of migraine: a blinded study. Cephalalgia. 2006;26(1):74-80.

Santos-Lasaosa S, Viloria-Alebesque A, Morandeira-Rivas C, Val LJ Lopes Del, Bellosta-Diago E, Velezquez-Benito A. Mnemonic complaints and chronic migraine. Rev Neurol. 2013;57(4):145-9.

Hooker WD, Raskin NH. Neuropsychologic alterations in classic and common migraine. Arch Neurol. 1986;43(7):709-12.

Zeitlin C, Oddy M. Cognitive impairment in patients with severe migraine. Br J Clin Psychol. 1984;23:27-35.

Baena C Pellegrino, Goulart AC, Santos IS, Suemoto CK, Lotufo PA, Bensenor IJ. Migraine and cognitive function: baseline findings from the Brazilian longitudinal study of adult health: ELSA-Brasil. Cephalalgia. 2017.

Schwedt TJ, Dodick DW. Advanced neuroimagem of migraine. Lancet Neurol. 2009;8(6):560-8.

Lee S, Sziklas V, Andermann F, Farnham S, Risse G, Gustafson M. The effects of adjunctive topiramate on cognitive function in patients with epilepsy. Epilepsia. 2003;44(3):339-47.

Yasuda CL, Centeno M, Vollmar C, Stretton J, Symms M, Cendes F. The effect of topiramate on cognitive fMRI. Epilepsy Res. 2013;105(1-2):250-5.

Loring DW, Williamson DJ, Meador KJ, Wiegand F, Hilihan J. Topiramate dose effects on cognition: a randomized double-blind study. Neurology. 2011;76(2):131-7.

Ferreira KS, Teixeira CT, Cáfaro C, Oliver GZ, Carvalho GL, Carvalho LA. Comprometimento cognitivo em pacientes com migrânea crônica é independente do uso de topiramato e comorbidades. Headache Med. 2017;3(8):89.

Diagnostic and statistical manual of mental disorders - DSM - 5. 2013.

Memória CM, Yassuda MS, Nakano EY, Forlenza OV. Brief screening for mild cognitive impairment: validation of Brazilian version of the Montreal cognitive assessment. Int J Geriatr Psychiatry. 2013;28(1):34-40.

Stroop JR. Studies interference in serial verbal reactions. J Exp Psychol. 1935;18:643-62.

SAS/ STAT User´s Guide. 1999.

Landrø NI, Fors EA, Våpenstad LL, Holthe Ø, Stiles TC, Borchgrevink PC. The extent of neurocognitive dysfunction in a multidisciplinary pain centre population. Is there a relation between reported and tested neuropsychological functioning?. Pain. 2013;154(7):972-7.

Silberstein SD, Hulihan J, Karim MR, Wu SC, Jordan D, Karvois D. Efficacy and tolerability of topiramate 200 mg/d in the prevention of migraine with/without aura in adults: a randomized, placebo-controlled, double-blind, 12-week pilot study. Clin Ther. 2006;28(7):1002-11.

Submitted date:
01/21/2018

Accepted date:
06/11/2018

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