Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20190048
Brazilian Journal of Pain
Review Article

Systemic alterations in plasma biomarkers levels in patients with chronic pain

Alterações nos níveis plasmáticos de biomarcadores de pacientes com dor crônica

Leticia Meda Vendrusculo-Fangel; Renan Fangel; Rita de Cássia Marqueti

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Abstract

BACKGROUND AND OBJECTIVES: To analyze the scientific evidence on the changes in plasma levels of interleukins, nitric oxide, extracellular matrix metalloproteinases, bradykinins, and cortisol in patients with chronic pain.

CONTENTS: The studies were identified by searching the following electronic databases: Pubmed/Medline, Scopus, LILACS, and Web of Science, published from June of 2016 to December of 2016. The selected articles were presented in a flow chart based on their identification, selection, eligibility and inclusion and exclusion criteria. The content of the articles included in the study was analyzed to identify the biomarkers present in patients with chronic pain. Thirteen articles that addressed the plasma biomarkers levels in humans with chronic pain were selected. Most of the articles presented the cytokines levels, followed by cortisol. Only one article mentioned the nitric oxide, and none mentioned what plasma levels of extracellular matrix metalloproteinases and bradykinins were identified.

CONCLUSION: Changes were observed in inflammatory and anti-inflammatory cytokine plasma levels, and that cortisol is related to anxiety and depression symptoms in patients with chronic pain. However, it was not possible to identify the changes in plasma levels of nitric oxide, bradykinin, and extracellular matrix metalloproteinases due to the absence of scientific evidence.

Keywords

Biomarkers, Chronic pain, Plasma

Resumo

JUSTIFICATIVA E OBJETIVOS: Analisar as evidências científicas sobre alterações nos níveis plasmáticos de interleucinas, óxido nítrico, metaloproteinases de matriz extracelular, bradicinina e cortisol em pacientes com dor crônica.

CONTEÚDO: Os estudos foram identificados por meio das bases de dados eletrônicas: Pubmed/Medline, Scopus, LILACS e Web of Science, publicados no período de junho a dezembro de 2016. Os artigos selecionados foram classificados em ficha de identificação, seleção dos participantes, elegibilidade, critérios de inclusão e exclusão. Os artigos selecionados foram avaliados por meio de análise de conteúdo, buscando identificar os biomarcadores presentes nos pacientes com dor crônica. Foram selecionados 13 artigos que abordavam a dosagem plasmática de biomarcadores em humanos com dor crônica. A maior parte dos artigos apresentou a dose de citocinas, seguidos pelo cortisol. Apenas um artigo apresentou a dose de óxido nítrico e nenhum artigo identificou a dosagem de níveis plasmáticos de metaloproteinases de matriz extracelular e bradicinina.

CONCLUSÃO: Pôde-se verificar modificações nos níveis plasmáticos de citocinas inflamatórias e anti-inflamatórias, e que os níveis plasmáticos de cortisol estão relacionados com os sintomas de ansiedade e depressão nos pacientes com dor crônica. No entanto, não foi possível verificar as alterações nos níveis de plasma do óxido nítrico, bradicinina e metaloproteinase de matriz extracelular devido à ausência de evidências científicas.

Palavras-chave

Biomarcadores, Dor crônica, Plasma

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Submitted date:
09/16/2018

Accepted date:
01/07/2019

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