Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20200020
Brazilian Journal of Pain
Original Article

Association between migraine, constipation and lactose intolerance in adults patients

Associação entre enxaqueca, constipação intestinal e intolerância à lactose em adultos

Lorraine Lacerda Brasil Souza; Luana de Oliveira Leite; Carina Marcia Magalhães Nepomuceno

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Abstract

BACKGROUND AND OBJECTIVES: Considering the bidirectional connection between intestine and brain, the present study examined the association between migraine, lactose intolerance, and intestinal constipation in patients with status migrainosus.

METHODS: This is a cross-sectional retrospective study that included 97 patients aged 20 years or older. The impact of pain was assessed by the Migraine Disability Assessment and the Headache Impact Test-6 questionnaires. The pain intensity was measured by the visual analog scale. Chi-square and Student-t tests were used for the statistical analysis.

RESULTS: The sample consisted of 88.7% women, 56.8% overweight, 76.3% sedentary, 32% constipated and 23.7% lactose intolerant. Higher pain intensity (8.9±1.3) and impact pain mean was assessed by the Headache Impact Test-6 (67.6±5.3) and the Migraine Disability Assessment (36.7±26.3) in constipated patients compared to those without constipation. Lactose-intolerant patients presented higher migraine mean time (19.9±14.2) compared to lactose tolerant patients. Constipated and lactose intolerant patients presented higher prevalence of overweight (58.1 and 65.2%) and abdominal obesity (70.0 and 68.2%) compared to non-constipated and lactose tolerant patients, respectively.

CONCLUSION: Although were observed in the evaluated sample a considerable prevalence of constipation and lactose intolerance, higher mean scores in the questionnaires used for pain impact and intensity in constipated patients and longer migraine diagnosis time in those with lactose-intolerance, there was no statistical significance in the association between migraine and these two gastrointestinal disorders.

Keywords

Constipation, Dysbiosis, Headache, Lactose intolerance, Migraine disorders

Resumo

JUSTIFICATIVA E OBJETIVOS: Ao considerar a conexão bidirecional entre intestino e cérebro, o presente estudo avaliou a associação entre enxaqueca, intolerância à lactose e constipação intestinal em pacientes em estado migranoso.

MÉTODOS: Trata-se de um estudo transversal e retrospectivo que incluiu 97 pacientes com idade igual ou superior a 20 anos. O impacto da dor foi avaliado pelos questionários: Migraine Disability Assessment e Headache Impact Test-6. A intensidade da dor foi avaliada pela escala analógica visual. Os testes Qui-quadrado e Student-t foram utilizados para análise estatística.

RESULTADOS: A amostra foi composta por 88,7% de mulheres, 56,8% com excesso de peso, 76,3% sedentários, 32% constipados e 23,7% intolerantes à lactose. Os constipados apresentaram maiores médias de impacto da dor pelo Headache Impact Test-6 (67,6±5,3) e pelo Migraine Disability Assessment (36,7±26,3) e intensidade da dor (8,9±1,3) do que os não constipados. Os pacientes intolerantes à lactose apresentaram maior média de tempo de enxaqueca (19,9±14,2) em relação aos tolerantes à lactose. Os pacientes constipados apresentaram maiores prevalências de excesso de peso (58,1 e 65,2%) e obesidade abdominal (70,0 e 68,2%) e intolerantes em relação aos sem constipação intestinal e aos tolerantes à lactose, respectivamente.

CONCLUSÃO: Embora identificadas prevalências consideráveis de constipação intestinal e intolerância à lactose na amostra avaliada, além de maiores médias de pontuação nos questionários utilizados para impacto e intensidade da dor nos pacientes constipados e de maior tempo de diagnóstico da migrânea nos intolerantes à lactose, não houve significância estatística na associação entre enxaqueca e esses distúrbios gastrointestinais.

Palavras-chave

Cefaleia, Constipação intestinal, Disbiose, Intolerância à lactose, Transtornos de enxaqueca

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Submitted date:
09/22/2019

Accepted date:
03/09/2020

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