Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20200030
Brazilian Journal of Pain
Original Article

Evaluation of nociception induced by whole-body vibration remobilization in Wistar rats

Avaliação da nocicepção induzida pela remobilização com vibração de corpo inteiro em ratos Wistar

Maria Luiza Serradourada Wutzke; Ana Luiza Peretti; Lucinéia de Fátima Chasko Ribeiro; Alberito Rodrigo de Carvalho; Gladson Ricardo Flor Bertolini

http://dx.doi.org/10.5935/2595-0118.20200030 BrJP, vol.3, n2, p.94-98, 2020
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Abstract

BACKGROUND AND OBJECTIVES: The vibrating platform can attenuate the deleterious effects of immobilization related to muscle atrophy. However, there is still a gap regarding the effect of this modality on hyperalgesia related to immobilization. The objective of this study was to analyze the effect of remobilization with whole-body vibration on the nociception of Wistar rats.

METHODS: Sixteen rats were randomly distributed into two groups: the FRG group - immobilization and free remobilization and the VPRG - immobilization and remobilization with the vibrating platform. For remobilization with the vibrating platform, the frequency of 60Hz for 10 minutes, five days a week for two weeks was used. The nociception was evaluated on the right paw by a digital analgesiometer, before and at the end of the immobilization, and after two weeks of remobilization.

RESULTS: There were differences between evaluations but not between groups, indicating that immobilization reduced the nociceptive threshold and free remobilization, and the remobilization associated with vibration improved the nociceptive threshold compared to the post-immobilization moment. However, they were not able to return to the initial parameters.

CONCLUSION: Joint immobilization reduced the nociceptive threshold; however, two weeks of whole-body vibration remobilization were not able to revert the threshold in the immobilized groups.

Keywords

Hyperalgesia, Immobilization, Vibration

Resumo

JUSTIFICATIVA E OBJETIVOS: A plataforma vibratória pode atenuar os efeitos deletérios da imobilização relacionados à atrofia muscular, contudo, ainda há uma lacuna com relação ao efeito desta modalidade na hiperalgesia relacionada ao imobilismo. Assim, o objetivo deste estudo foi analisar o efeito da remobilização com plataforma vibratória sobre a nocicepção de ratos Wistar.

MÉTODOS: Dezesseis ratos foram distribuídos aleatoriamente no grupo GRL - imobilização e remobilização livre, e no grupo GRPV - imobilização e remobilização com plataforma vibratória. Para a remobilização com plataforma vibratória foi utilizada a frequência de 60Hz, durante 10 minutos, cinco dias por semana, durante duas semanas. A nocicepção foi avaliada na pata direita, por meio de um analgesímetro digital, antes e ao final da imobilização, e após duas semanas de remobilização.

RESULTADOS: Houve diferenças entre as avaliações, mas não entre os grupos, indicando que a imobilização reduziu o limiar nociceptivo, e a remobilização livre e associada à vibração melhoraram o limiar nociceptivo comparados com o momento pós-imobilização, no entanto, não foram capazes de retornar aos parâmetros iniciais.

CONCLUSÃO: A imobilização articular reduziu o limiar nociceptivo. No entanto, duas semanas de remobilização com a vibração de corpo inteiro não foram capazes de reverter o limiar nos grupos imobilizados.

Palavras-chave

Hiperalgesia, Imobilização, Vibração

References

Al-Mohrej OA, Al-Kenani NS. Acute ankle sprain: conservative or surgical approach?. EFORT Open Rev. 2016;1(2):34-44.

Omidi A, Zargar F. Effect of mindfulness-based stress reduction on pain severity and mindful awareness in patients with tension headache: a randomized controlled clinical trial. Nurs Midwifery Stud. 2014;3(3).

Kunz RI, Coradini JG, Silva LI, Bertolini GR, Brancalhão RM, Ribeiro LF. Effects of immobilization and remobilization on the ankle joint in Wistar rats. Braz J Med Biol Res. 2014;47(10):842-9.

Szostakowski B, Smitham P, Khan WS. Plaster of Paris-short history of casting and injured limb immobilzation. Open Orthop J. 2017;11(1):291-6.

Santos-Júnior FF, Pires Ade F, Ribeiro NM, Mendonça VA, Alves JO, Soares PM. Sensorial, structural and functional response of rats subjected to hind limb immobilization. Life Sci. 2015;137:158-63.

Hamaue Y, Nakano J, Sekino Y, Chuganji S, Sakamoto J, Yoshimura T. Effects of vibration therapy on immobilization-induced hypersensitivity in rats. Phys Ther. 2015;95(7):1015-26.

Hamaue Y, Nakano J, Sekino Y, Chuganji S, Sakamoto J, Yoshimura T. Immobilization-induced hypersensitivity associated with spinal cord sensitization during cast immobilization and after cast removal in rats. J Physiol Sci. 2013;63(6):401-8.

Goswami N, Blaber AP, Hinghofer-Szalkay H, Montani JP. Orthostatic intolerance in older persons: etiology and countermeasures. Front Physiol. 2017;8:803.

Chuganji S, Nakano J, Sekino Y, Hamaue Y, Sakamoto J, Okita M. Hyperalgesia in an immobilized rat hindlimb: effect of treadmill exercise using non-immobilized limbs. Neurosci Lett. 2015;584:66-70.

Neumann S, Doubell TP, Leslie T, Woolf CJ. Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons. Nature. 1996;384(6607):360-4.

Sekino Y, Nakano J, Hamaue Y, Chuganji S, Sakamoto J, Yoshimura T. Sensory hyperinnervation and increase in NGF, TRPV1 and P2X3 expression in the epidermis following cast immobilization in rats. Eur J Pain. 2014;18(5):639-48.

Rocha AP, Kraychete DC, Lemonica L, Carvalho LR, Barros GA, Garcia JB. Dor: aspectos atuais da sensibilização periférica e central. Rev Bras Anestesiol. 2007;57(1):94-105.

Silva LI, Meireles A, Nascimento CM, Rocha BP, Rosa CT, Ribeiro LFC. Avaliação de parâmetros histomorfométricos em sóleos de ratos submetidos à remobilização por salto em meio aquático. Rev Bras Med Esporte. 2013;19(3):219-22.

Koike TE, Watanabe AY, Kodama FY, Ozaki GAT, Castoldi RC, Garcia TA. Exercício físico após imobilização de músculo esquelético de ratos adultos e idosos. Rev Bras Med Esporte. 2018;24(1):60-3.

Ozaki GAT, Koike TE, Castoldi RC, Garçon AAB, Kodama FY, Watanabe AY. Efeitos da remobilização por meio de exercício físico sobre a densidade óssea de ratos adultos e idosos. Motricidade. 2014;10(3):71-8.

Rittweger J. Vibration as an exercise modality: How it may work, and what its potential might be. Eur J Appl Physiol. 2010;108(5):877-904.

Cerciello S, Rossi S, Visonà E, Corona K, Oliva F. Clinical applications of vibration therapy in orthopaedic practice. Muscles Ligaments Tendons J. 2016;6(1):147-56.

Hallal CZ, Marques NR, Gonçalves M. O uso da vibração como método auxiliar no treinamento de capacidades físicas: uma revisão da literatura. Motriz. 2010;16(2):527-33.

Bidonde J, Busch AJ, van der Spuy I, Tupper S, Kim SY, Boden C. Whole body vibration exercise training for fibromyalgia. Cochrane Database Syst Rev. 2017;2017(9):CD011755.

Moreira-Marconi E, Moura-Fernandes MC, Teixeira-Silva Y, Sá-Caputo DC, Silva-Costa G, Carvalho SO. Exercícios de vibração de corpo inteiro beneficiam indivíduos com osteoartrite do joelho: uma revisão narrativa. Rev Hosp Univ Pedro Ernesto. 2018;17(1):44-50.

Simão AP, Avelar NC, Tossige-Gomes R, Neves CD, Mendonça VA, Miranda AS. Functional performance and inflammatory cytokines after squat exercises and whole-body vibration in elderly individuals with knee osteoarthritis. Arch Phys Med Rehabil. 2012;93(10):1692-700.

Camilo IR, Wutzke MLS, Costa RM, Bertolini GRF, Ribeiro LFC. Morphology of extensor digitorum longus of Wistar rats after remobilization by vibratory platform. Eur J Clin Exp Med. 2020;17(4):295-300.

Kaneguchi A, Ozawa J, Kawamata S, Kurose T, Yamaoka K. Intermittent whole-body vibration attenuates a reduction in the number of the capillaries in unloaded rat skeletal muscle. BMC Musculoskelet Disord. 2014;15:315.

Kakihata CMM, Peretti AL, Wutzke MLS, Tavares ALF, Ribeiro LFC, Brancalhão RMC. Morphological and nociceptive effects of mechanical vibration on the sciatic nerve of oophorectomized Wistar rats. Motriz: Rev Educ Fis. 2019;25(1).

Peretti AL, Kakihata CMM, Wutzke MLS, Torrejais MM, Ribeiro LFC, Bertolini GRF. Effects of mechanical vibration in neuromuscular junctions and fiber type of the soleus muscle of oophorectomized wistar rats. Rev Bras Ortop. 2019;54(5):572-8.

Ohmichi M, Ohmichi Y, Ohishi H, Yoshimoto T, Morimoto A, Li Y. Activated spinal astrocytes are involved in the maintenance of chronic widespread mechanical hyperalgesia after cast immobilization. Mol Pain. 2014;10:6.

Ashmawi HA, Freire GM. Sensibilização periférica e central. Rev Dor. 2016;17(Suppl 1):S31-4.

Guo TZ, Wei T, Li WW, Li XQ, Clark JD, Kingery WS. Immobilization contributes to exaggerated neuropeptide signaling, inflammatory changes, and nociceptive sensitization after fracture in rats. J Pain. 2014;15(10):1033-45.

Baig HA, Guarino BB, Lipschutz D, Winkelstein BA. Whole body vibration induces forepaw and hind paw behavioral sensitivity in the rat. J Orthop Res. 2013;31(11):1739-44.

Dong Y, Wang W, Zheng J, Chen S, Qiao J, Wang X. Whole body vibration exercise for chronic musculoskeletal pain: a systematic review and meta-analysis of randomized controlled trials. Arch Phys Med Rehabil. 2019;100(11):2167-78.

Submitted date:
02/11/2020

Accepted date:
04/15/2020

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