Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20210053
Brazilian Journal of Pain
Original Article

Chronic neuropathic pain: quality of life, depressive symptoms and distinction between genders

Dor crônica neuropática: qualidade de vida, sintomas depressivos e distinção entre os sexos

Laura Figueiredo Villa; Ana Marcia Rodrigues Cunha; Lilian Andreia Chessa Dias; Marcos Henrique Dall'aglio Foss; Marielza Regina Ismael Martins

http://dx.doi.org/10.5935/2595-0118.20210053 BrJP, vol.4, n4, p.301-305, 2021
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Abstract

BACKGROUND AND OBJECTIVES: Neuropathic pain is a chronic pain which can be accompanied by comorbidities, such as sleep interferences and anxiety. The present study aimed to evaluate the neuropathic chronic pain impact and its comorbidities in life quality and depression symptoms, comparing this impact between genders.

METHODS: Thirty female and 30 male patients were evaluated. The research was based on the following instruments: half structured interview with sociodemographic questions, World Health Organization Quality of Life-BREF questionnaire, Beck Depression Inventory, pain signs and symptoms by Leeds Assessment of Neuropathic Symptoms and Signs, visual analog scale and drugs adherence by Morisky-Green test.

RESULTS: As for quality of life, the physical domain was the most affected and only the psychological domain showed statistical differences between genders (p=0.031). The depression symptoms were observed in 56.7% of all patients, without important statistical difference between the genders (p=0,830). The median of pain intensity was 8.0 points, indicating severe pain intensity among these patients. The medical adherence happened among women and men, respectively in 7 (23.3%) and 11 (36.7%) of the patients (p=0.260).

CONCLUSION: The presence of neuropathic pain and its comorbidities strongly and negatively affects quality of life and is related to depressive symptoms, with similar prevalence in both genders, although women have a greater impact on their quality of life.

Keywords

Chronic pain, Depression, Gender distribution, Quality of life

Resumo

JUSTIFICATIVA E OBJETIVOS: A dor neuropática é uma dor crônica que pode se apresentar junto com comorbidades, como interferências no sono e ansiedade. O presente estudo teve como objetivo avaliar o impacto da dor crônica neuropática e suas comorbidades na qualidade de vida e sintomas depressivos, comparando esse impacto entre os sexos.

MÉTODOS: Foram incluídos 30 pacientes do sexo feminino e 30 do sexo masculino. Os instrumentos utilizados foram: entrevista semiestruturada com questões sociodemográficas, questionário de qualidade de vida World Health Organization Quality of Life-BREF, Inventário Beck de Depressão, sinais e sintomas da dor através do questionário Leeds Assessment of Neuropathic Symptoms and Signs, escala analógica visual e adesão farmacológica pelo teste de Morisky-Green.

RESULTADOS: Em relação a qualidade de vida, o domínio físico foi o mais acometido e apenas o domínio psicológico apresentou diferença estatística entre os sexos (p=0,031). Os sintomas depressivos foram observados em 56,7% dos pacientes, sem diferença significante entre os sexos (p=0,830). A mediana de intensidade dolorosa foi 8,0 pontos, indicando dor intensa nesses pacientes. A adesão farmacológica foi menor nas mulheres que nos homens, respectivamente, em 7 (23,3%) e 11 (36,7%) pacientes (p=0,260).

CONCLUSÃO: A presença de dor neuropática e suas comorbidades impacta negativamente a qualidade de vida e está relacionada com sintomas depressivos, com prevalência semelhante nos dois sexos, apesar de as mulheres apresentarem maior impacto na qualidade de vida.

Palavras-chave

Depressão, Distribuição por sexo, Dor crônica, Qualidade de vida

References

Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D. Neuropathic pain. Nat Rev Dis Primers. 2017;3(1):1-9.

Posso ID, Palmeira CC, Vieira ÉB. Epidemiologia da dor neuropática. Rev Dor. 2016;17(1):11-4.

Popescu A, Leresche L, Truelove EL, Drangsholt MT. Gender differences in pain modulation by diffuse noxious inhibitory controls: a systematic review. Pain. 2010;150(2):309-18.

Coraggio V, Guida F, Boccella S, Scafuro M, Paino S, Romano D. Neuroimmune-driven neuropathic pain establishment: a focus on gender differences. Int J Mol Sci. 2018;19(1):281.

Maurer AJ, Lissounov A, Knezevic I, Candido KD, Knezevic NN. Pain and sex hormones: a review of current understanding. Pain Manag. 2016;6(3):285-96.

Packiasabapathy S, Sadhasivam S. Gender, genetics, and analgesia: understanding the differences in response to pain relief. J Pain Res. 2018;11:2729.

Finnerup NB, Sindrup SH, Jensen TS. The evidence for pharmacological treatment of neuropathic pain. Pain. 2010;150(3):573-81.

Nicholson B, Verma S. Comorbidities in chronic neuropathic pain. Pain Med. 2004;5(Suppl1):S9-27.

Taloyan M, Löfvander M. Depression and gender differences among younger immigrant patients on sick leave due to chronic back pain: a primary care study. Prim Health Care Res Dev. 2014;15(1):5-14.

Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-98.

Fleck MP, Louzada S, Xavier M, Chachamovich E, Vieira G, Santos L. Application of the Portuguese version of the abbreviated instrument of quality life WHOQOL-bref. Rev Saude Publica. 2000;34(2):178-83.

Castro SM, Trentini C, Riboldi J. Item response theory applied to the Beck Depression Inventory. Rev Bras Epidemiol. 2010;13(3):487-501.

Eckeli FD, Teixeira RA, Gouvêa AL. Neuropathic pain evaluation tools. Rev Dor. 2016;17(Suppl 1):S20-2.

Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986;24(1):67-74.

Conover WJ. Practical nonparametric statistics. 1998.

Field A. Discovering Statistics Using IBM SPSS Statistics. 2013.

Silva ZP, Ribeiro MC, Barata RB, Almeida MF. Perfil sociodemográfico e padrão de utilização dos serviços de saúde do Sistema Único de Saúde (SUS), 2003-2008. Ciênc Saúde Coletiva. 2011;16(9):3807-16.

Celik S, Yenidunya G, Temel E, Purisa S, Uzum AK, Gul N. Utility of DN4 questionnaire in assessment of neuropathic pain and its clinical correlations in Turkish patients with diabetes mellitus. Prim Care Diabetes. 2016;10(4):259-64.

Gilron I, Baron R, Jensen T. Neuropathic pain: principles of diagnosis and treatment. Mayo Clinic Proceedings. 2015;90:532-45p.

Zilliox LA. Neuropathic pain. Continuum (Minneap Minn). 2017;23(2):512-32.

Cherif F, Zouari HG, Cherif W, Hadded M, Cheour M, Damak R. Depression prevalence in neuropathic pain and its impact on the quality of life. Pain Res Manag. 2020;16:7408508.

Shrestha R, Silwal P, Basnet N, Shakya Shrestha S, Shrestha R, Pokharel BR. A prospective study of commonly prescribed drugs in the management of neuropathic pain and its medication adherence pattern. Kathmandu Univ Med J. 2016;14(53):47-53.

Timmerman L, Stronks DL, Groeneweg JG, Huygen FJ. Prevalence and determinants of medication non-adherence in chronic pain patients: a systematic review. Acta Anaesthesiol Scand. 2016;60(4):416-31.

Maia RD. Recent trends in neuropathic pain patents. Expert Opin Ther Pat. 2017;27(5):539-46.

VanDenKerkhof EG, Stitt L, Clark AJ, Gordon A, Lynch M, Morley-Forster PK. Sensitivity of the DN4 in screening for neuropathic pain syndromes. Clin J Pain. 2018;34(1):30-6.

Husky MM, Farin FF, Compagnone P, Fermanian C, Kovess-Masfety V. Chronic back pain and its association with quality of life in a large French population survey. Health Qual Life Out. 2018;16(1):1-9.

Jaworska S, Ryan K. Gender and the language of pain in chronic and terminal illness: a corpus-based discourse analysis of patients' narratives. Soc Sci Med. 2018;215:107-14.

Sternke EA, Abrahamson K, Bair MJ. Comorbid chronic pain and depression: patient perspectives on empathy. Pain Manag Nurs. 2016;17(6):363-71.

Submitted date:
02/02/2020

Accepted date:
09/13/2021

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