Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20230021-en
Brazilian Journal of Pain
Review Article

Use of medical cannabis in the treatment of endometriosis

Utilização da cannabis medicinal no tratamento da endometriose

Patrick Bellelis; Carolina Fernandes Giacometti

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Abstract

BACKGROUND AND OBJECTIVES: Endometriosis is a common gynecological condition, which affects 10% to 15% of women in the reproductive period and up to half of women with chronic pelvic pain and/or infertility. It is estimated that the number of women with endometriosis is 8 million in Brazil and more than 190 million worldwide. In industrialized countries, it is one of the main causes of gynecological hospitalization. The objective of this study was to evaluate the medical literature on the use of cannabis in the treatment of endometriosis.
CONTENTS: Cannabis is increasingly available for the treatment of chronic pain, but its effectiveness remains uncertain due to the lack of randomized trials. 
CONCLUSION: Limited evidence suggests that cannabis may relieve pain in some patients, but there is insufficient evidence regarding dose, formulations and best route of administration that precludes a definitive recommendation on cannabis for the relief of chronic pelvic pain of gynecological origin. 

Keywords

Cannabis, Endometriosis, Pharmacological treatment.

Resumo

JUSTIFICATIVA E OBJETIVOS: A endometriose é uma afecção ginecológica comum que atinge de 10% a 15% das mulheres no período reprodutivo e até metade das mulheres com dor pélvica crônica e/ou infertilidade. Estima-se que o número de mulheres com endometriose seja de 8 milhões no Brasil e de mais de 190 milhões no mundo. Em países industrializados, é uma das principais causas de hospitalização ginecológica. O objetivo deste estudo foi avaliar a literatura médica sobre o uso da cannabis no tratamento da endometriose.
CONTEÚDO: A cannabis está cada vez mais disponível para o tratamento da dor crônica, mas sua eficácia permanece incerta devido à insuficiência de estudos randomizados. 
CONCLUSÃO: As evidências limitadas sugerem que a cannabis pode aliviar a dor em alguns pacientes, mas existem evidências insuficientes em relação a dose, formulações e melhor via de administração, o que impede uma recomendação definitiva da cannabis para alívio da dor pélvica crônica de origem ginecológica.

Palavras-chave

Cannabis, Endometriose, Tratamento farmacológico

References

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Submitted date:
07/20/2023

Accepted date:
02/27/2023

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