Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20230059-en
Brazilian Journal of Pain
Review Article

Pediatric patients and medical cannabis: new trends

Pacientes pediátricos e cannabis medicinal: novas tendências

Sandra Caires Serrano; Fabiana Gomes de Campos; Valesca Oliveira Paes Tanaka

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Abstract

BACKGROUND AND OBJECTIVES: Despite the ancestral use of cannabinoids in adults, safety and efficacy in children is unclear. The impact of cannabis on the developing brain is unknown1 While studies conducted in adults can provide insight into the efficacy/toxicity profile of cannabis, there is a need for specific studies in children and adolescents to understand the impact of cannabis on the developing brain, as well as the potential long-term effects of cannabis use. The objective of this study was to bring a comprehensive view and critical discussion on the subject.
CONTENTS: A narrative review based on research in the Pubmed, Medline and Scielo databases was prepared, with an open theme and a selective literature review in the context of the pediatric population.
CONCLUSION: Current research on the impact of medical cannabis use in children and adolescents remains limited4, which reinforces the need for robust studies in this population.

Keywords

Cancer, Medical cannabis, Pediatrics

Resumo

JUSTIFICATIVA E OBJETIVOS: Apesar do uso ancestral de canabinoides em adultos, a segurança e eficácia na população infantil não é clara. O impacto da cannabis no cérebro em desenvolvimento é desconhecido1. Embora estudos realizados em adultos possam oferecer informações sobre o perfil de eficácia/toxicidade da cannabis, há necessidade de estudos específicos em crianças e adolescentes para compreender o impacto da cannabis no cérebro em desenvolvimento, bem como os potenciais efeitos a longo prazo do uso de cannabis. O objetivo deste estudo foi trazer uma visão abrangente e discussão crítica sobre o tema.  
CONTEÚDO: Foi elaborada uma revisão narrativa baseada em pesquisas nas bases de dados Pubmed, Medline e Scielo, com temática aberta e revisão de literatura seletiva no contexto da população pediátrica.
CONCLUSÃO: A pesquisa atual sobre o impacto do uso da cannabis medicinal em crianças e adolescentes permanece limitada4, o que reforça a necessidade de estudos robustos sobre essa população.

Palavras-chave

Câncer, cannabis medicinal, Pediatria

References

1 Yeung M, Wroot H, Charnock C, Forbes C, Lafay-Cousin L, Schulte F. Cannabis use in pediatric cancer patients: what are they reading? A review of the online literature. Support Care Cancer. 2020;28(8):3503-15.

2 Chanda D, Neumann D, Glatz JFC. The endocannabinoid system: overview of an emerging multi-faceted therapeutic target. Prostaglandins Leukot Essent Fatty Acids. 2019;140:51-6.

3 Russo EB, Hohmann AG. Role of cannabinoids in pain management. In: Comprehensive treatment of chronic pain by medical, interventional, and integrative approaches. Springer, New York. 2013. 181-97p.

4 Mandelbaum DE, de la Monte SM. Adverse structural and functional effects of marijuana on the brain: evidence reviewed. Pediatr Neurol. 2017;66:12-20.

5 Fisher E, Eccleston C, Degenhardt L, Finn DP, Finnerup NB, Gilron I, Haroutounian S, Krane E, Rice ASC, Rowbotham M, Wallace M, Moore RA. Cannabinoids, cannabis, and cannabis-based medicine for pain management: a protocol for an overview of systematic reviews and a systematic review of randomised controlled trials. Pain Rep. 2019;4(3):e741.

6 Eccleston C, Fisher E, Cooper TE, Grégoire MC, Heathcote LC, Krane E, Lord SM, Sethna NF, Anderson AK, Anderson B, Clinch J, Gray AL, Gold JI, Howard RF, Ljungman G, Moore RA, Schechter N, Wiffen PJ, Wilkinson NMR, Williams DG, Wood C, van Tilburg MAL, Zernikow B. Pharmacological interventions for chronic pain in children: an overview of systematic reviews. Pain. 2019;160(8):1698-707.

7 Andradas C, Truong A, Byrne J, Endersby R. The role of cannabinoids as anticancer agents in pediatric oncology. Cancers (Basel). 2021;13(1):157.

8 Lynch ME, Campbell F. Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials. Br J Clin Pharmacol. 2011;72(5):735-44.
 


Submitted date:
09/10/2022

Accepted date:
07/07/2023

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