Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20230084-en
Brazilian Journal of Pain
Review Article

Incidence and impacts of pain in intensive care units: systematic review

Incidência e impactos da dor em unidades de terapia intensiva:  revisão sistemática

Iura Gonzalez Alves; Rafaela Dias Bezerra; Bianca Borges de Brito

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Abstract

BACKGROUND AND OBJECTIVES: In Intensive Care Units (ICU), patients are exposed to multiple procedures that can be painful, and health professionals are not always aware of the pain in these patients. Inadequate pain assessment and management, in turn, has been associated with several adverse outcomes, including an increased rate of infection, prolonged mechanical ventilation, hemodynamic disturbances, delirium, and compromised immunity. Thus, this study aimed to summarize the scientific evidence about the incidence and impacts of pain in critically ill patients.
CONTENTS: A systematic review of observational studies (Pubmed and EMBASE databases) was performed with predetermined eligibility criteria. In the 32 studies included, it was identified that 10.1% to 61% of patients had pain at rest and 27.4% to 94% during procedures. In addition, there was evidence of improvement in patient outcomes after using validated instruments for pain measurement, including decreased length of ICU stay, duration of mechanical ventilation, mortality, delirium, adverse events, and disease severity.
CONCLUSION: Through the present study, it was observed that pain is a common phenomenon in ICU and that its identification and management constitute a realistic goal and depend on the evaluation. Furthermore, pain appears to be associated with worse clinical outcomes. Therefore, efforts must be made to provide comprehensive care for critically ill patients, aiming not only at their survival, but also at alleviating their suffering.

Keywords

Association measure, Exposure risk or outcome, Intensive care unit, Pain, Pain measurement, Systematic review

Resumo

JUSTIFICATIVA E OBJETIVOS: Nas Unidades de Terapia Intensiva (UTI) os pacientes são expostos a múltiplos procedimentos que podem ser dolorosos, e nem sempre os profissionais de saúde estão alertas para a dor nesses pacientes. A avaliação e o manejo inadequado da dor, por sua vez, têm sido associados a uma série de resultados adversos, incluindo aumento da taxa de infecção, ventilação mecânica prolongada, distúrbios hemodinâmicos, delírio e imunidade comprometida. Dessa forma, este estudo teve como objetivo sumarizar as evidências científicas acerca da incidência e dos impactos da dor em pacientes críticos. 
CONTEÚDO: Foi realizada uma revisão sistemática de estudos observacionais (bases de dados Pubmed e EMBASE) com critérios de elegibilidade predeterminados. Nos 32 estudos incluídos, foi identificado que de 10,1% a 61% dos pacientes apresentaram dor em repouso, e de 27,4% a 94% apresentaram dor durante os procedimentos. Além disso, houve evidências de melhora nos resultados dos pacientes após o uso de instrumentos validados para a mensuração da dor, incluindo diminuição do tempo de permanência na UTI, duração da ventilação mecânica, mortalidade, delírio, eventos adversos e gravidade da doença.
CONCLUSÃO: Através do presente estudo foi observado que a dor representa um fenômeno comum nas UTI e que a sua identificação e manejo constitui uma meta realista e dependente da avaliação. Além disso, a dor parece estar associada a piores desfechos clínicos. Sendo assim, deve-se voltar esforços para o cuidado integral ao paciente crítico, objetivando não só sua sobrevivência, mas também o alívio do seu sofrimento.

Palavras-chave

Dor, Exposição risco ou desfecho, Medição da dor, Medida de associação, Revisão sistemática, Unidade de terapia intensiva

References

1 Cade CH. Clinical tools for the assessment of pain in sedated critically ill adults. Nurs Crit Care. 2008;13(6):288-97.

2 Georgiou E, Hadjibalassi M, Lambrinou E, Andreou P, Papathanassoglou ED. The impact of pain assessment on critically ill patients’ outcomes: a systematic review. Biomed Res Int. 2015;2015:503830.

3 Abdullayev R, Uludag O, Celik B. Analgesia nociception index: assessment of acute postoperative pain. Braz J Anesthesiol. 2019;69(4):396-402.

4 Sakata RK. Analgesia e sedação em unidade de terapia intensiva. Rev Bras Anestesiol. 2010;60(6):653-8.

5 Queiroz Sierra A, Ayres Ximenes Ponte Colaço M, Martins Soares Cruz B. Avaliação da dor em UTI adulta no Brasil através da “Behavioral Pain Scale”: revisão sistemática. 43ª ed. Vol. 14. Rev Inspirar. 2017.

6 Ribeiro AS, Santos JPN, Araújo DC, Santos ES, Magalhães FB, Pinheiro FG. Dor, agitação e sedoanalgesia em pacientes críticos internados em unidade de terapia intensiva. Farmacologia Aplicada à Enfermagem: Aspectos Teóricos e Práticos. 2020;27:74-86.

7 Chanques G, Sebbane M, Barbotte E, Viel E, Eledjam JJ, Jaber S. A prospective study of pain at rest: incidence and characteristics of an unrecognized symptom in surgical and trauma versus medical intensive care unit patients. Anesthesiology. 2007;107(5):858-60.

8 Kotfis K, Zegan-Barańska M, Szydłowski Ł, Żukowski M, Ely WE. Methods of pain assessment in adult intensive care unit patients - Polish version of the CPOT (Critical Care Pain Observation Tool) and BPS (Behavioral Pain Scale). Anesthesiol Intensive Ther. 2017;49(1):66-72.

9 Pinheiro ARPQ, Marques RMD. Behavioral Pain Scale and Critical Care Pain Observation Tool for pain evaluation in orotracheally tubed critical patients. A systematic review of the literature. Rev Bras Ter Intensiva. 2019;31(4):571-81.

10 Damico V, Macchi G, Murano L, Forastieri Molinari A. Incidence of pain at rest and during nursing procedures in ICU patients: a longitudinal observational study. Ann Ig. 2020;32(4):407-18.

11 Latorre Marco I, Solís Muñoz M, Falero Ruiz T, Larrasquitu Sánchez A, Romay Pérez AB, Millán Santos I. Validación de la escala de conductas indicadoras de dolor para valorar el dolor en pacientes críticos, no comunicativos y sometidos a ventilación mecánica: resultados del proyecto ESCID. Enferm Intensiva. 2011;22(1):2-12.

12 López-López C, Arranz-Esteban A, Arias-Rivera S, Solís-Muñoz M, Pérez-Pérez T, Latorre-Marco I. Application of the Behavioural Indicators of Pain Scale in patients with traumatic brain injury. J Adv Nurs. 2020;76(7):1862-70.

13 Karcioglu O, Topacoglu H, Dikme O, Dikme O. A systematic review of the pain scales in adults: which to use? Am J Emerg Med. 2018;36(4):707-14.

14 JBI Manual for Evidence Synthesis. Aromataris E, Munn Z, editors. JBI; 2020.

15 Everingham K, Salisbury L, Lapinlampi P, Cornwall I, Frame F, Walsh T. Agitation and pain during physiotherapy in intensive care. Crit Care. 2010;14(Suppl 1):492.

16 Ayasrah S. Care-related pain in critically III mechanically ventilated patients. Anaesth Intens Care. 2016;44(4):458-65.

17 Robleda G, Roche-Campo F, Membrilla-Martínez L, Fernández-Lucio A, Villamor-Vázquez M, Merten A, Gich I, Mancebo J, Català-Puigbó E, Baños JE. Evaluación del dolor durante la movilización y la aspiración endotraqueal en pacientes críticos. Med Intensiva. 2016;40(2):96-104.

18 Chanques G, Jaber S, Barbotte E, Violet S, Sebbane M, Perrigault PF, Mann C, Lefrant JY, Eledjam JJ. Impact of systematic evaluation of pain and agitation in an intensive care unit. Crit Care Med. 2006;34(6):1691-9.

19 Thikom N, Thongsri R, Wongcharoenkit P, Khruamingmongkhon P, Wongtangman K. Incidence of inadequate pain treatment among ventilated, critically ill surgical patients in a Thai population. Pain Manag Nurs. 2021;22(3):336-42.

20 López-López C, Pérez-Pérez T, Beneit-Montesinos JV, García-Klepzig JL, Martinez-Ureta MV, Murillo-Pérez MDA, Torrente-Vela SA, García-Iglesias M. Pain Assessment in Mechanically Ventilated, Noncommunicative Severe Trauma Patients. J Trauma Nurs. 2018;25(1):49-59.

21 Olsen BF, Valeberg BT, Jacobsen M, Småstuen MC, Puntillo K, Rustøen T. Pain in intensive care unit patients-a longitudinal study. Nurs Open. 2020;8(1):224-31.

22 Cazorla C, Cravoisy A, Gibot S, Nace L, Levy B, Bollaert PE. Perception par les patients de leur séjour en réanimation [Patients’ perception of their experience in the intensive care unit]. Presse Med. 2007;36(2 Pt 1):211-6

23 Yamashita A, Yamasaki M, Matsuyama H, Amaya F. Risk factors and prognosis of pain events during mechanical ventilation: a retrospective study. J Intensive Care. 2017;5:17.

24 Nelson JE, Meier DE, Oei EJ, Nierman DM, Senzel RS, Manfredi PL, Davis SM, Morrison RS. Self-reported symptom experience of critically ill cancer patients receiving intensive care. Crit Care Med. 2001;29(2):277-82.

25 Shan K, Cao W, Yuan Y, Hao JJ, Sun XM, He X, Li GY, Wang YM, Zhou JX. Use of the critical-care pain observation tool and the bispectral index for the detection of pain in brain-injured patients undergoing mechanical ventilation: A STROBE-compliant observational study. Medicine (Baltimore). 2018;97(22):e10985.

26 López-López C, Murillo-Pérez MA, Morales-Sánchez C, Torrente-Vela S, Orejana-Martín M, García-Iglesias M, Cuenca-Solanas M, Alted-López E. Valoración del dolor en la aspiración de secreciones traqueales en pacientes con traumatismo craneal mediante la Escala de conductas indicadoras de dolor (ESCID) [Pain assessment of tracheal suctioning on brain injury patients by pain behavioral indicator scale (ESCID)]. Enferm Intensiva. 2014;25(3):114-21.

27 Ito Y, Teruya K, Nakajima E. Evaluation of pain severity in critically ill patients on mechanical ventilation. Intensive Crit Care Nurs. 2022;68:103118.

28 López-Alfaro MP, Echarte-Nuin I, Fernández-Sangil P, Moyano-Berardo BM, Goñi-Viguria R. Perception of pain in post-surgical patients in intensive care units. Enferm Intensiva. 2019.30(3):99-107.

29 Olsen BF, Rustøen T, Sandvik L, Jacobsen M, Valeberg BT. Results of implementing a pain management algorithm in intensive care unit patients: The impact on pain assessment, length of stay, and duration of ventilation. J Crit Care. 2016;36:207-11.

30 Radtke FM, Heymann A, Franck M, Maechler F, Drews T, Luetz A, Nachtigall I, Wernecke KD, Spies CD. How to implement monitoring tools for sedation, pain and delirium in the intensive care unit: an experimental cohort study. Intensive Care Med. 2012;38(12):1974-81.

31 Faust AC, Rajan P, Sheperd LA, Alvarez CA, McCorstin P, Doebele RL. Impact of an analgesia-based sedation protocol on mechanically ventilated patients in a medical intensive care unit. anesthesia and analgesia. 2016;123(4):903-9.

32 Payen JF, Bosson JL, Chanques G, Mantz J, Labarere J. Pain assessment is associated with decreased duration of mechanical ventilation in the intensive care unit. Anesthesiology. 2009;111(6):1308-16.

33 Arbour C, Gélinas C, Michaud C. Impact of the implementation of the critical-care pain observation tool (cpot) on pain management and clinical outcomes in mechanically ventilated trauma intensive care unit patients. J Trauma Nurs. 2011;18(1):52-60.

34 Skrobik Y, Ahern S, Leblanc M, Marquis F, Awissi DK, Kavanagh BP. Protocolized intensive care unit management of analgesia, sedation, and delirium improves analgesia and subsyndromal delirium rates. Anesth Analg. 2010;111(2):451-63.

35 Kress JP, Pohlman AS, O’Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342(20):1471-7.

36 Trogrlić Z, van der Jagt M, Bakker J, Balas MC, Ely EW, van der Voort PH, Ista E. A systematic review of implementation strategies for assessment, prevention, and management of ICU delirium and their effect on clinical outcomes. Crit Care. 2015;19(1):157.

37 Rose L, Haslam L, Dale C, Knechtel L, McGillion M. Behavioral pain assessment tool for critically ill adults unable to self-report pain. Am J Crit Care. 2013;22(3):246-55.

38 Williams TA, Martin S, Leslie G, Thomas L, Leen T, Tamaliunas S, Lee KY, Dobb G. Duration of mechanical ventilation in an adult intensive care unit after introduction of sedation and pain scales. Am J Crit Care. 2008;17(4):349-56.

39 Elseoud WA. et al. Pain is a problem during critical care. In: 42º International Symposium on Intensive Care & Emergency Medicine. P093.

40 Fratino S, Garré A, Garufi A, Hafidi S, Migliorino E, Stropeni S, Bogossian EG, Ndieugnou Djangang N, Albano G, Creteur J, Peluso L, Taccone FS. Evaluation of nociception in unconscious critically ill patients using a multimodal approach. Anaesth Crit Care Pain Med. 2023;42(2):101175.

41 Meehan D, McRae M, Rourke D, Eisenring C, Imperial F. Analgesic administration, pain intensity, and patient satisfaction in cardiac surgical patients. Am J Crit Care. 1995;4(6):435-42.

42 Onyeneke JC, Hanlon K, Peters M, Smoot CA, Jennings JH, Swiderek JL, Digiovine B. Introduction of sedation protocol for intubated patients in a medical intensive care unit. Am J Respir Crit Care Med 2018;197.

43 Böhmer AB, Mutert J, Poels M, Arends S, Lefering R, Gerbershagen MU, Wappler F, Joppich R. Pain intensity and treatment in patients with multiple trauma before and after implementation of a quality management system in acute pain therapy — a retrospective analysis. 2016;57:6-13.

44 Santos Oliveira L, Pimentel Macedo M, Silva S, Oliveira AP, Santos V. Pain assessment in critical patients using the Behavioral Pain Scale. BrJP. 2019;2(2):112-6.

45 Wojnar-Gruszka K, Sega A, Płaszewska-Żywko L, Wojtan S, Potocka M, Kózka M. Pain Assessment with the BPS and CCPOT Behavioral Pain scales in mechanically ventilated patients requiring analgesia and sedation. Int J Environ Res Public Health. 2022;19(17):10894.

46 Hora TC, Alves IG. Escalas para a avaliação da dor na unidade de terapia intensiva. Revisão sistemática. BrJP. 2020.3(3):263-74.

47 Dinse CM, Bucher M, Burgdorff AM, Christel A, Flöther L. Pain management in surgical intensive care patients: a retrospective observational research. Medicine (Baltimore). 2022;101(46):e31297.
 


Submitted date:
07/09/2023

Accepted date:
09/21/2023

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