Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.63231/2595-0118.202555-en
Brazilian Journal of Pain
Original Article

Sociodemographic profile, adherence, and drug interactions in patients with chronic pain treated by the Specialized Pharmaceutical Care Component of Blumenau: cross-sectional study

Perfil sociodemográfico, adesão e interações farmacológicas em pacientes com dor crônica atendidos pelo Componente Especializado da Assistência Farmacêutica de Blumenau: estudo transversal

Helena Luiza Kirsten Sasse; Luana Gabriele Nilson; Mônica Cristina Nunes

http://dx.doi.org/10.63231/2595-0118.202555-en BrJP, vol.8, e202555, 2025
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Abstract

JUSTIFICATIVA E OBJETIVOS: Chronic pain (CP) is a multifactorial condition that significantly affects patients’ quality of life. Classified according to its pathophysiological mechanism, CP presents a variety of therapeutic challenges, in addition to its significant economic and social impact. The aim of this study was to define the sociodemographic profile, assess drugs adherence and potential drug interactions of patients diagnosed with chronic pain who take their drugs from the Specialized Component of Pharmaceutical Assistance (CEAF - Componente Especializado da Assistência Farmacêutica).

METHODS: Two instruments were used to assess drug adherence: the Morisky-Green Test (TMG) and the Brief Medication Questionnaire (BMQ). To evaluate the agreement between them, the Kappa coefficient was applied. There was a prevalence of women, white, predominantly aged between 40 and 59, married and with incomplete primary education. The search for drug interactions identified the concomitant use of gabapentin and tramadol, resulting in a high-risk interaction.

RESULTS: The results of the TMG indicated 65% of patients with moderate adherence and the BMQ 60% with probable low adherence, with 95% scoring in the recall domain. The Kappa coefficient showed moderate agreement at 0.58.

CONCLUSION: Pharmaceutical monitoring is essential to guide the use of drugs, identifying interactions and promoting greater adherence to treatment.

Keywords

Chronic pain; Drugs from the Specialized; Drug interactions; Drug therapy; Component of Pharmaceutical Care; Medication adherence

Resumo

JUSTIFICATIVA E OBJETIVOS: A dor crônica (DC) é uma condição multifatorial que afeta significativamente a qualidade de vida dos pacientes. Classificada segundo seu mecanismo fisiopatológico, a DC apresenta desafios terapêuticos variados, além do seu significativo impacto econômico e social. O objetivo deste estudo foi definir o perfil sociodemográfico, avaliar a adesão farmacológica e as interações farmacológicas potenciais de pacientes diagnosticados com DC que retiram seu fármaco no Componente Especializado da Assistência Farmacêutica (CEAF).

MÉTODOS: Foram aplicados dois instrumentos de avaliação da adesão ao tratamento: o teste de Morisky-Green (TMG) e o Brief Medication Questionnaire (BMQ). Para verificar a concordância entre eles, utilizou-se o coeficiente Kappa. Houve prevalência de mulheres, cor branca, faixa etária predominante entre 40 e 59 anos, casados e ensino fundamental incompleto. A busca por interações farmacológicas identificou o uso concomitante de gabapentina e tramadol resultando em interação de risco elevado.

RESULTADOS: Os resultados do TMG indicaram 65% dos pacientes com moderada adesão e o BMQ 60% de provável baixa adesão, sendo que 95% pontuaram no domínio recordação. O coeficiente Kappa apresentou concordância moderada de 0,58.

CONCLUSÃO: O acompanhamento farmacêutico tornasse fundamental para orientar o uso dos fármacos, identificando interações e promovendo maior adesão ao tratamento.

Palavras-chave

Adesão à medicação; Dor crônica; Interações farmacológicas; Medicamentos do Componente Especializado da Assistência Farmacêutica; Tratamento farmacológico

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Submitted date:
06/30/2026

Accepted date:
11/14/2025

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