Transcutaneous electrical nerve stimulation in the treatment of pain in breast cancer patients: systematic review
Estimulação elétrica nervosa transcutânea no tratamento da dor em pacientes com câncer de mama: revisão sistemática
Ana Luisa Tenani Pereira da Costa; Enzo Vicari Santana; Loami Robert Moreira Barbosa; Dernival Bertoncello; Márcia Rosângela Buzanello; Gladson Ricardo Flor Bertolini
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1 Katsura C, Ogunmwonyi I, Kankam HK, Saha S. Breast cancer: presentation, investigation and management. Br J Hosp Med. 2022;83(2):1-7.
2 Barzaman K, Karami J, Zarei Z, Hosseinzadeh A, Kazemi MH, Moradi-Kalbolandi S, Safari E, Farahmand L. Breast cancer: Biology, biomarkers, and treatments. Int Immunopharmacol. 2020;84:106535.
3 Jacobs AT, Martinez Castaneda-Cruz D, Rose MM, Connelly L. Targeted therapy for breast cancer: an overview of drug classes and outcomes. Biochem Pharmacol. 2022;204:115209.
4 El Masri J, Phadke S. Breast cancer epidemiology and contemporary breast cancer care: A review of the literature and clinical applications. Clin Obstet Gynecol. 2022;65(3):461-81.
5 Mendonça ACR, Rett MT, Garcez PA, Aquino MJV, Lima LV, DeSantana JM. TENS effects on dysesthesia and quality of life after breast cancer surgery with axilectomy: randomized controlled trial. Fisioter Mov. 2017;30(suppl 1):285-95.
6 Panis C, Pavanelli WR. Cytokines as mediators of pain‐related process in breast cancer. Mediators Inflamm. 2015;2015(1):129034.
7 De Groef A, Van Kampen M, Dieltjens E, Christiaens MR, Neven P, Geraerts I, Devoogdt N. Effectiveness of postoperative physical therapy for upper-limb impairments after breast cancer treatment: A systematic review. Arch Phys Med Rehabil. 2015;96(6):1140-53.
8 Cho Y, Do J, Jung S, Kwon O, Jeon JY. Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection. Support Care Cancer. 2016;24(5):2047-57.
9 Greenlee H, DuPont‐Reyes MJ, Balneaves LG, Carlson LE, Cohen MR, Deng G, Johnson JA, Mumber M, Seely D, Zick SM, Boyce LM, Tripathy D. Clinical practice guidelines on the evidence‐based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin. 2017;67(3):194-232.
10 Cramer H, Lauche R, Klose P, Lange S, Langhorst J, Dobos GJ. Yoga for improving health-related quality of life, mental health and cancer-related symptoms in women diagnosed with breast cancer. Cochrane Database Syst Rev. 2017;1:CD010802.
11 Wu Y, Zhu F, Chen W, Zhang M. Effects of transcutaneous electrical nerve stimulation (TENS) in people with knee osteoarthritis: A systematic review and meta-analysis. Clin Rehabil. 2022;36(4):472-85.
12 Vance CG, Dailey DL, Rakel BA, Sluka KA. Using Tens for pain control: the state of the evidence. Pain Manag (Lond). 2014;4(3):197-209.
13 Valero EG, Miranda CDR, Arrieta SC, Morelli MID, Butnaru DS, Carrillo MR, et al. Nonpharmacological interventions for postmastectomy pain syndrome: a systematic review of the literature. Clin Breast Cancer. 2025;25(2):e133, 151.e6.
14 Wang Z, Deng H, Liao L, Lu T, Li X. Excitatory and inhibitory effects of stimulation of sacral dorsal root ganglion on bladder reflex in cats. Int Urol Nephrol. 2018;50(12):2179-86.
15 Ren J, Chew DJ, Thiruchelvam N. Electrical stimulation of the spinal dorsal root inhibits reflex bladder contraction and external urethra sphincter activity: is this how sacral neuromodulation works? Urol Int. 2016;96(3):360-6.
16 Artuç ŞE, Uçkun AÇ, Sivas FA, Yurdakul FG, Bodur H. Comparison of the effects of transcutaneous electrical nerve stimulation and interferential current therapies in central sensitization in patients with knee osteoarthritis. Korean J Pain. 2023;36(3):392-403.
17 Hugosdottir R, Kasting M, Mørch CD, Andersen OK, Arendt-Nielsen L. Priming of central and peripheral mechanisms with heat and cutaneous capsaicin facilitates secondary hyperalgesia to high-frequency electrical stimulation. J Neurophysiol. 2022;127(3):651-9.
18 Leemans L, Elma Ö, Nijs J, Wideman TH, Siffain C, den Bandt H, Van Laere S, Beckwée D. Transcutaneous electrical nerve stimulation and heat to reduce pain in a chronic low back pain population: a randomized controlled clinical trial. Braz J Phys Ther. 2021;25(1):86-96.
19 Sluka KA, Lisi TL, Westlund KN. Increased release of serotonin in the spinal cord during low, but not high, frequency transcutaneous electric nerve stimulation in rats with joint inflammation. Arch Phys Med Rehabil. 2006;87(8):1137-40.
20 Ezema CI, Onyeso OK, Nna EO, Awosoga OA, Odole AC, Kalu ME, Okoye GC. Transcutaneous electrical nerve stimulation effects on pain-intensity and endogenous opioids levels among chronic low-back pain patients: a randomised controlled trial. J Back Musculoskelet Rehabil. 2022;35(5):1053-64.
21 Elshinnawy AM, Eraky ZS, Abdelaziz SS, Abd‐Elrahman NAF. Effect of cold application versus transcutaneous nerve stimulation on chemotherapy induced diabetic peripheral neuropathy post mastectomy. Physiother Res Int. 2024;29(1):e2051.
22 Robb KA, Newham DJ, Williams JE. Transcutaneous electrical nerve stimulation vs. transcutaneous spinal electroanalgesia for chronic pain associated with breast cancer treatments. J Pain Symptom Manage. 2007;33(4):410-9.
23 Silva JG, Santana CG, Inocêncio KR, Orsini M, Machado S, Bergmann A. Electrocortical analysis of patients with intercostobrachial pain treated with TENS after breast cancer surgery. J Phys Ther Sci. 2014;26(3):349-53.
24 Püsküllüoğlu M, Tomaszewski KA, Grela-Wojewoda A, Pacholczak-Madej R, Ebner F. Effects of transcutaneous electrical nerve stimulation on pain and chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review. Medicina. 2022;58(2):284.
25 Sluka KA, Walsh D. Transcutaneous electrical nerve stimulation: basic science mechanisms and clinical effectiveness. J Pain. 2003;4(3):109-21.
26 Schleder JC, Verner FA, Mauda L, Mazzo DM, Fernandes LC. The transcutaneous electrical nerve stimulation of variable frequency intensity has a longer-lasting analgesic action than the burst transcutaneous electrical nerve stimulation in cancer pain. Rev Dor. 2017;18(4):316-20.
27 Johnson MI, Paley CA, Howe TE, Sluka KA. Transcutaneous electrical nerve stimulation for acute pain. Cochrane Database Syst Rev. 2015;2015(6):CD006142.
28 Mokhtari T, Ren Q, Li N, Wang F, Bi Y, Hu L. Transcutaneous electrical nerve stimulation in relieving neuropathic pain: basic mechanisms and clinical applications. Curr Pain Headache Rep. 2020;24(4):14.
29 Hurlow A, Bennett MI, Robb KA, Johnson MI, Simpson KH, Oxberry SG. Transcutaneous Electric Nerve Stimulation (TENS) for cancer pain in adults. Cochrane Database Syst Rev. 2012;2012(3):CD006276.
Submitted date:
09/30/2025
Accepted date:
02/03/2026
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