Randomized crossover clinical trial protocol to evaluate the immediate effects of electromassage on pain in hemato-oncological patients
Protocolo de ensaio clínico randomizado cruzado para avaliar os efeitos imediatos da eletromassagem na dor em pacientes hemato-oncológicos
Giovanne Pereira da Costa; Maria Eduarda Somariva Rochi; Mariana Gabriela Figueira Farinhaque Maderna Leite; Rodrigo de Barros Zannata; Natália Boneti Moreira; Raciele Ivandra Guarda Korelo
Abstract
Keywords
Resumo
Palavras-chave
Referências
1 Daud ML, Simone GG. Management of pain in cancer patients: an update. Ecancermedicalscience. 2024;18:1821.
2 Mestdagh F, Steyaert A, Lavand’homme P. Cancer pain management: a narrative review of current concepts, strategies, and techniques. Curr Oncol. 2023;30(7):6838-58.
3 Paice JA, Bohlke K, Barton D, Craig DS, El-Jawahri A, Hershman DL, Kong LR, Kurita GP, LeBlanc TW, Mercadante S, Novick KLM, Sedhom R, Seigel C, Stimmel J, Bruera E. Use of opioids for adults with pain from cancer or cancer treatment: ASCO guideline. J Clin Oncol. 2023;41(4):914-30.
4 Granger CL. Physiotherapy management of blood cancers. J Physiother. 2023;69(2):70-8.
5 Barbosa IM, Sales DS, Oliveira LMS, Sampaio DM, Milhome AG. Pain in onco-hematologic patients and its association with analgesia. Rev Dor. 2016;17(3):178-82.
6 Daud ML, Simone GG. Management of pain in cancer patients: an update. Ecancermedicalscience. 2024;18:1821.
7 Manitta V, Zordan R, Cole-Sinclair M, Nandurkar H, Philip J. The symptom burden of patients with hematological malignancy: a cross-sectional observational study. J Pain Symptom Manage. 2011;42(3):432-42.
8 Li QY, Yang WX, Yao LQ, Chen H, Li ZR, Gong YB, Shi J. Exploring the rules of related parameters in transcutaneous electrical nerve stimulation for cancer pain based on data mining. Pain Ther. 2023;12(6):1355-74.
9 Zhang Y, Wang S, Ma X, Yuan Y, Cheng H, Lin L, Tian L. Massage therapy can effectively relieve cancer pain: A meta-analysis. Medicine. 2023;102(27):e33939.
10 Albornoz-Cabello M, Sanchez-Santos JA, Melero-Suarez R, Heredia-Rizo AM, Espejo-Antunez L. Effects of adding interferential therapy electro-massage to usual care after surgery in subacromial pain syndrome: a randomized clinical trial. J Clin Med. 2019;8(2):175.
11 Piras A, Zini L, Trofè A, Campa F, Raffi M. Effects of Acute Microcurrent Electrical Stimulation on Muscle Function and Subsequent Recovery Strategy. Int J Environ Res Public Health. 2021;18(9):4597.
12 Hjermstad MJ, Fayers PM, Haugen DF, Caraceni A, Hanks GW, Loge JH, Fainsinger R, Aass N, Kaasa S, and the European Palliative Care Research Collaborative (EPCRC). Studies comparing Numerical Rating Scales, Verbal Rating Scales, and Visual Analogue Scales for assessment of pain intensity in adults: a systematic literature review. J Pain Symptom Manage. 2011;41(6):1073-93.
13 Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, Carbone PP. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5(6):649-55.
14 Siemens W, Boehlke C, Bennett MI, Offner K, Becker G, Gaertner J. Transcutaneous electrical nerve stimulation for advanced cancer pain inpatients in specialist palliative care-a blinded, randomized, sham-controlled pilot cross-over trial. Support Care Cancer. 2020;28(11):5323-33.
15 Post-White J, Kinney ME, Savik K, Gau JB, Wilcox C, Lerner I. Therapeutic massage and healing touch improve symptoms in cancer. Integr Cancer Ther. 2003;2(4):332-44.
16 Kutner JS, Smith MC, Corbin L, Hemphill L, Benton K, Mellis BK, Beaty B, Felton S, Yamashita TE, Bryant LL, Fairclough DL. Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trial. Ann Intern Med. 2008;149(6):369-79.
17 Gewandter JS, Chaudari J, Ibegbu C, Kitt R, Serventi J, Burke J, Culakova E, Kolb N, Sluka KA, Tejani MA, Mohile NA. Wireless transcutaneous electrical nerve stimulation device for chemotherapy-induced peripheral neuropathy: an open-label feasibility study. Support Care Cancer. 2019;27(5):1765-74.
18 Ferreira KA, Teixeira MJ, Mendonza TR, Cleeland CS. Validation of brief pain inventory to Brazilian patients with pain. Support Care Cancer. 2011;19(4):505-11.
19 Ishikawa NM. Validação do FACT-F no Brasil e avaliação da fadiga e qualidade de vida em mulheres com câncer de mama [tese]. Campinas: Universidade Estadual de Campinas; 2009.
20 Rodgers-Melnick SN, Bartolovich M, Desai NJ, Vasanna SH, Rivard RL, Owusu-Ansah A, Ahuja SP, Dusek JA, Miller DW. Massage therapy for children, adolescents, and young adults: clinical delivery and effectiveness in hematology and oncology. Pediatr Blood Cancer. 2023;70(4):e30243.
21 Ferguson L, Scheman J. Patient global impression of change scores within the context of a chronic pain rehabilitation program. J Pain. 2009;10(4):S73.
22 Olsen MF, Bjerre E, Hansen MD, Hilden J, Landler NE, Tendal B, Hróbjartsson A. Pain relief that matters to patients: systematic review of empirical studies assessing the minimum clinically important difference in acute pain. BMC Med. 2017;15(1):35.
23 Lee DK. Alternatives to P value: confidence interval and effect size. Korean J Anesthesiol. 2016;69(6):555-62.
24 Gupta SK. Intention-to-treat concept: a review. Perspect Clin Res. 2011;2(3):109-12.
25 Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, Ripamonti CI, and the ESMO Guidelines Committee. Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines. Ann Oncol. 2018;29(Suppl. 4):iv166-91.
26 Snijders RAH, Brom L, Theunissen M, van den Beuken-van Everdingen MHJ. Update on Prevalence of Pain in Patients with Cancer 2022: A Systematic Literature Review and Meta-Analysis. Cancers. 2023;15(3):591.
27 Stout NL, Santa Mina D, Lyons KD, Robb K, Silver JK. A systematic review of rehabilitation and exercise recommendations in oncology guidelines. CA Cancer J Clin. 2021;71(2):149-75.
28 National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Survivorship. Plymouth: NCCN; 2019.
29 Robb K, Oxberry SG, Bennett MI, Johnson MI, Simpson KH, Searle RD. A cochrane systematic review of transcutaneous electrical nerve stimulation for cancer pain. J Pain Symptom Manage. 2009;37(4):746-53.
30 Hurlow A, Bennett MI, Robb KA, Johnson MI, Simpson KH, Oxberry SG. Transcutaneous electric nerve stimulation (TENS) for cancer pain in adults. Cochrane Database Syst Rev. 2012;2012(3):CD006276.
31 Carvalho CP, Tomaz SSS, Wilchez CM, Biaggi AC, Lunardi C, Carniel CF, Castiglione M, Estevão A. Transcutaneous electrical nerve stimulation (TENS) in cancer patients: an integrative review. Braz Journ Health Review. 2021;4(5):22440-54.
32 Nakano J, Ishii K, Fukushima T, Ishii S, Ueno K, Matsuura E, Hashizume K, Morishita S, Tanaka K, Kusuba Y. Effects of transcutaneous electrical nerve stimulation on physical symptoms in advanced cancer patients receiving palliative care. Int J Rehabil Res. 2020;43(1):62-8.
33 Johnson MI. Resolving long-standing uncertainty about the clinical efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) to relieve pain: a comprehensive review of factors influencing outcome. Medicina. 2021;57(4):378.
34 Deng G. Integrative medicine therapies for pain management in cancer patients. Cancer J. 2019;25(5):343-8.
35 Fernández-Morales C, Albornoz-Cabello M, Cardero-Durán MLÁ, Moreno-Vázquez JM, Espejo-Antúnez L. Effectiveness of a multimodal physiotherapy program in fighter pilots with flight-related neck pain: a randomized controlled trial. PM R. 2025;17(11):1308-20.
36 Lara-Palomo IC, Aguilar-Ferrándiz ME, Matarán-Peñarrocha GA, Saavedra-Hernández M, Granero-Molina J, Fernández-Sola C, Castro-Sánchez AM. Short-term effects of interferential current electro-massage in adults with chronic non-specific low back pain: a randomized controlled trial. Clin Rehabil. 2013;27(5):439-49.
37 Korelo R, Pesaski A, Santos NL, Silva NP, Anjos RAS, Vojciechowski AS, Macedo ACB, Gallo RBS, Korelo RIG. Effects of high-intensity interval training associated to microcurrent on localized adiposity: protocol of randomized clinical trial. MTP & Rehab Journal. 2020;18:780.
38 Vlaar AP, ten Klooster PM, Taal E, Gheith RE, El-Garf AK, Rasker JJ, van de Laar MA. A cross-cultural study of pain intensity in Egyptian and Dutch women with rheumatoid arthritis. J Pain. 2007;8(9):730-6.
Submetido em:
17/10/2025
Aceito em:
10/02/2026
Facebook
Google+
Twitter
LinkedIn
Mendeley
Email