Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20190015
Brazilian Journal of Pain
Review Article

Adherence to fibromyalgia treatment: challenges and impact on the quality of life

Adesão ao tratamento da fibromialgia: desafios e impactos na qualidade de vida

José Oswaldo de Oliveira Júnior; Júlia Villegas Campos Ramos

http://dx.doi.org/10.5935/2595-0118.20190015 BrJP, vol.2, n1, p.81-87, 2019
PDF English
PDF Português
SciELO
Downloads: 0
Views: 612

Abstract

BACKGROUND AND OBJECTIVES: Fibromyalgia is a chronic and idiopathic syndrome, characterized by a general distributed pain, more prevalent in women. Its pathophysiology remains unclear. Its chronicity implies an exclusively symptomatic treatment, often unsatisfactory. The lack of adherence to the established treatment is quite common. The objective of this study is to present a review of the adherence to the fibromyalgia syndrome treatment.

CONTENTS: The concept of adherence to the fibromyalgia syndrome treatment, its classification, the identification of its measurement options, and the detection of its causes are detailed, revised and updated.

CONCLUSION: The review of the literature regarding the adherence to the fibromyalgia syndrome treatment points to a large number of nonconformity of prescription, in general with the prevalence of the adoption of the reduction of the recommended dose and the interruption of the treatment, over possible overdoses and self-medication. The study of the causes that led to the non-adherence to the treatment elects the characteristics of the syndrome as the great villain for its occurrence. However, other associated factors such as the age of the subject with fibromyalgia, the intensity of the pain, the established polypharmacy, the quality of the doctor-patient relationship and the socioeconomic variables were also listed. The patient's quality of life was always higher in patients with higher adherence to treatment and persistence. Patients' quality of life indices may indicate the level of commitment to treatment adherence, and vice versa.

Keywords

Adherence, Compliance, Fibromyalgia, Nonpharmacologic treatment, Persistence, Pharmacologic treatment, Therapeutic conformity

Resumo

JUSTIFICATIVA E OBJETIVOS: A fibromialgia é uma síndrome crônica e idiopática, caracterizada por queixa dolorosa de distribuição generalizada, mais prevalente em mulheres. A sua fisiopatologia continua não totalmente esclarecida. Sua cronicidade implica em tratamento exclusivamente sintomático e muitas vezes insatisfatório. A falta de adesão ao tratamento instituído é bastante comum. O objetivo deste estudo foi apresentar uma revisão sobre a adesão do tratamento da síndrome fibromiálgica.

CONTEÚDO: O conceito de adesão ao tratamento da síndrome fibromiálgica, sua classificação, a identificação das opções de sua mensuração, e a detecção de suas causas são detalhados, revisados e atualizados.

CONCLUSÃO: A revisão da literatura referente à adesão ao tratamento da síndrome fibromiálgica mostra um grande contingente de inconformidade de prescrição, em geral predominando a adoção da redução da dose orientada e a interrupção do próprio tratamento, sobre possíveis sobredoses e automedicações. O estudo das causas que levaram à falta de adesão ao tratamento elege as características da própria síndrome como a grande vilã para sua ocorrência; embora, tenham sido também elencados outros fatores associados como a idade do portador da síndrome fibromiálgica, a intensidade da dor, a polifarmácia instituída, a qualidade da relação médico-paciente, e as variáveis socioeconômicas. A qualidade de vida dos pacientes sempre foi maior naqueles cuja adesão e persistência ao tratamento foram maiores. Os índices de qualidade vida dos pacientes podem indicar o nível de comprometimento com a adesão ao tratamento, e vice-versa.

Palavras-chave

Adesão, Conformidade, Conformidade terapêutica, Fibromialgia, Persistência, Tratamento farmacológico, Tratamento não farmacológico

References

Lorente GD, Stefani LF, Martins MR. Cinesiofobia, adesão ao tratamento, dor e qualidade de vida em indivíduos com síndrome fibromiálgica. Rev Dor. 2014;15(2):121-5.

Sabaté E. Adherence to long-term therapies: evidence for action. 2003.

Oliveira Jr JO, Almeida MB. The current treatment of fibromyalgia. Br J Pain. 2018;1(3):255-62.

DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW. Patient adherence and medical treatment outcomes: a meta-analysis. Med Care. 2002;40(9):794-811.

Cramer JA. Partial medication compliance: the enigma in poor medical outcomes. Am J Manag Care. 1995;1(1):45-52.

Zyczynski TM, Coyne KS. Hypertension and current issues in compliance and patient outcomes. Curr Hypertens Rep. 2000;2(6):510-4.

Avorn J, Monette J, Lacour A, Bohn RL, Monane M, Mogun H. Persistence of use of lipid-lowering medications: cross-national study. JAMA. 1998;279(18):1458-62.

Howell N, Trotter R, Mottram DR, Rowe PH. Compliance with statins in primary care. Pharm J. 2004;272:1-40.

Burrell A, Wong P, Ollendorf D, Cramer JA. Defining compliance/adherence and persistence: ISPOR Special Interest Working Group. Value Health. 2005;8(6):A194-5.

Peterson AM, Nau DP, Cramer JA, Benner J, Gwadry-Sridhar F, Nichol M. A checklist for medication compliance and persistence studies using retrospective databases. Value Health. 2007;10(1):3-12.

Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA. Medication compliance and persistence: terminology and definitions. Value Health. 2008;11(1):44-7.

Razali MS, Yahya H. Compliance with treatment in schizophrenia: a drug intervention program in a developing country. Acta Psychiatr Scand. 1995;91(5):331-5.

Tebbi CK. Treatment compliance in childhood and adolescence. Cancer. 1993;71(10):3441-9.

Timmerman L, Stronks DL, Groeneweg JG, Huygen FJ. Prevalence and determinants of medication non-adherence in chronic pain patients: a systematic review. Acta Anaesthesiol Scand. 2016;60(4):416-31.

Cardoso MG, Weinstock JG, Sardá Júnior JJ. Adhesion to neuropathic pain treatment. Rev Dor. 2016;17(^sSuppl 1):S107-9.

Kurita GP, Pimenta CA. Compliance with the treatment of chronic pain and health locus. Rev Esc Enferm USP. 2004;38(3):254-61.

Mastroianni PC, Oliveira AR, Nadai TR, Lucchetta RC. Economic indicators for drug acquisition. J Bras Econ Saúde. 2017;9(2):177-84.

Heymann RE, Paiva Edos S, Helfenstein Jr M, Pollak DF, Martinez JE, Provenza JR. Brazilian consensus on the treatment of fibromyalgia. Rev Bras Reumatol. 2010;50(1):56-66.

Bordson SJ, Atayee RS, Ma JD, Best BM. Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing. Pain Med. 2014;15(3):355-63.

Cui Z, Zhao Y, Novick D, Faries D. Predictors of duloxetine adherence and persistence in patients with fibromyalgia. J Pain Res. 2012;5:193-201.

Able S, Cui Z, Shen W. Medication adherence and persistence in patients treated with duloxetine. Value Health. 2012;15(4):A1-256.

Sanchez RJ, Mardekian J, Clair AG, Cappelleri JC. Therapeutic and subtherapeutic dosing of pregabalin: medication adherence, healthcare resource utilization, and costs. Am J Pharm Benefits. 2012;4(4):158-64.

Dobkin PL, Sita A, Sewitch MJ. Predictors of adherence to treatment in women with fibromyalgia. Clin J Pain. 2006;22(3):286-94.

Hyland ME, Hinton C, Hill C, Whalley B, Jones RC, Davies AF. Explaining unexplained pain to fibromyalgia patients: finding a narrative that is acceptable to patients and provides a rationale for evidence based interventions. Br J Pain. 2016;10(3):156-61.

Kenny DT. Constructions of chronic pain in doctor-patient relationships: bridging the communication chasm. Patient Educ Couns. 2004;52(3):297-305.

Asbring P, Närvänen AL. Ideal versus reality: physicians perspectives on patients with chronic fatigue syndrome (CFS) and fibromyalgia. Soc Sci Med. 2003;57(4):711-20.

Perrot S, Choy E, Petersel D, Ginovker A, Kramer E. Survey of physician experiences and perceptions about the diagnosis and treatment of fibromyalgia. BMC Health Serv Res. 2012;12:356.

Clauw DJ. Fibromyalgia: more than just a musculoskeletal disease. Am Fam Physician. 1995;52(3):843-51.

Buckelew SP. Behavioral interventions and fibromyalgia. J Musculoskel Pain. 1994;2:153-61.

McCain GA. Treatment of fibromyalgia syndrome. J Musculoskel Pain. 1994;2:93-104.

Pioro-Boisset M, Esdaile JM, Fitzcharles MA. Alternative medicine use in fibromyalgia syndrome. Arthritis Care Res. 1996;9(1):13-7.

Burckhardt CS, Clark SR, Bennett RM. Fibromyalgia and quality of life: a comparative analysis. J Rheumatol. 1993;20(3):475-9.

Ryan S. Fibromyalgia: what help can nurses give?. Nurs Stand. 1995;9(37):25-8.

Uveges JM, Parker JC, Smarr KL, McGowan JF, Lyon MG, Irvin WS. Psychological symptoms in primary fibromyalgia syndrome: relationship to pain, life stress, and sleep disturbance. Arthritis Rheum. 1990;33(8):1279-83.

Wolfe F, Hawley DJ. Measurement of the quality of life in rheumatic disorders using the EuroQoL. Br J Rheumatol. 1997;36(7):786-93.

Henriksson CM. Longterm effects of fibromyalgia on everyday life. A study of 56 patients. Scand J Rheumatol. 1994;23(1):36-41.

Schaefer KM. Struggling to maintain balance: a study of women living with fibromyalgia. J Adv Nurs. 1995;21(1):95-102.

Marques AP, Ferreira EA, Matsutani LA, Pereira CA, Assumpção A. Quantifying pain threshold and quality of life of fibromyalgia patients. Clin Rheumatol. 2005;24(3):266-71.

Bolwijn PH, van Santen-Hoeufft MH, Baars HM, Kaplan CD, van der Linden S. The social network characteristics of fibromyalgia patients compared with healthy controls. Arthritis Care Res. 1996;9(1):18-26.

Bolwijn PH, van Santen-Hoeufft MH, Baars HM, van der Linden S. Social network characteristics in fibromyalgia or rheumatoid arthritis. Arthritis Care Res. 1994;7(1):46-9.

Verbunt JA, Pernot DH, Smeets RJ. Disability and quality of life in patients with fibromyalgia. Health Qual Life Outcomes. 2008;6:8.

Boisset-Pioro MH, Esdaile JM, Fitzcharles MA. Sexual and physical abuse in women with fibromyalgia syndrome. Arthritis Rheum. 1995;38(2):235-41.

Yi TI, Kim BK, Ha SA, Lim JY. The relationships between determination of treatment success and emotional factors in patients with chronic musculoskeletal pain. Ann Rehabil Med. 2014;38(1):77-83.

Strömbeck B, Ekdahl C, Manthorpe R, Wilkström I, Jacobsson L. Health-related quality of life in primary Sjögren's syndrome, rheumatoid arthritis and fibromyalgia compared to normal population data using SF-36. Scand J Rheumatol. 2000;29(1):20-8.

Culos-Reed SN, Brawley LR. Fibromyalgia, physical activity, and daily functioning: the importance of efficacy and health-related quality of life. Arthritis Care Res. 2000;13(6):343-51.

Moretti FA, Silva SS, Novoa CG. Characteristics and perception of social support by patients with fibromyalgia in Facebook. Br J Pain. 2018;1(1):4-8.

van Uden-Kraan CF, Drossaert CH, Taal E, Shaw BR, Seydel ER, van de Laar MA. Empowering processes and outcomes of participation in online support groups for patients with breast cancer, arthritis, or fibromyalgia. Qual Health Res. 2008;18(3):405-17.

Submitted date:
10/23/2018

Accepted date:
01/18/2019

5f1f97cd0e88255346dc677d brjp Articles
2595-3192 (Electronic) 2595-0118 (Printed)
BrJP ©2024 All rights reserved.

BrJP

Share this page
Page Sections