Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20200044
Brazilian Journal of Pain
Review Article

Effect of mesenchymal stem cells on the regeneration of structures associated with temporomandibular joint: narrative review

Efeito de células-tronco mesenquimais na regeneração das estruturas associadas à articulação temporomandibular: revisão narrativa

Caren Serra Bavaresco; Thiago Kreutz Grossmann; Daniela Seitenfus Rehm; Eduardo Grossmann

http://dx.doi.org/10.5935/2595-0118.20200044 BrJP, vol.3, n3, p.275-279, 2020
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Abstract

BACKGROUND AND OBJECTIVES: Temporomandibular disorders are the problems involving the masticatory muscles and/or the temporomandibular joint and, among them, the bone and joint disc degenerative processes stand out. However, an effective treatment for these cases has not yet been identified in the literature. Thus, the primary objective of this study was to evaluate the reparative potential of mesenchymal stem cells on degenerative changes in structures associated with the temporomandibular joint in humans and animal models.

CONTENTS: This narrative review included intervention trials in humans and animals that presented as an outcome variable the repair of joint discs and/or temporomandibular joint. The following databases were used: Pubmed, LILACS, Scielo and Google Scholar. Titles and abstracts were analyzed for the pre-selection of articles potentially eligible for inclusion in this review. The information collected from each article was included in a specific spreadsheet for this purpose containing the year of publication, article title, author’s name, study location, type of study, methodology, results, and conclusions. Two human studies and four animal studies were selected to compose the narrative review. In all studies presented, the presence of stem cells was able to improve the clinical, histological, and morphological parameters of the temporomandibular joint.

CONCLUSION: The use of stem cells seems to be effective in treating degenerative changes in temporomandibular joint associated structures in both animal and human models. However, due to the small number of studies and their heterogeneity, the results presented should be evaluated sparingly.

Keywords

Stem cells, Temporomandibular joint disc, Temporomandibular joint disorders

Resumo

JUSTIFICATIVA E OBJETIVOS: As desordens temporomandibulares constituem-se em um termo coletivo de problemas que envolvem os músculos mastigatórios e/ou a articulação temporomandibular. Dentre esses, destacam-se os processos degenerativos ósseos e do disco articular, contudo, ainda não foi identificado na literatura um tratamento eficaz para esses casos. Dessa forma, o objetivo desse estudo foi avaliar o potencial reparador das células-tronco mesenquimais sobre as alterações degenerativas das estruturas associadas à articulação temporomandibular em humanos e em modelos animais.

CONTEÚDO: Foram incluídos ensaios de intervenção em humanos e em animais que apresentassem como variável desfecho o reparo dos discos articulares e/ou da articulação temporomandibular. Foram realizadas buscas nas seguintes bases de dados: Pubmed, LILACS, Scielo e Google Acadêmico. Os títulos e resumos foram analisados para a pré-seleção dos artigos potencialmente elegíveis para sua inclusão. As informações coletadas de cada artigo foram incluídas em planilha específica para essa finalidade contendo o ano de publicação, título do artigo, nome do autor, local do estudo, tipo de estudo, metodologia, resultado e conclusões. Foram selecionados 2 estudos em humanos e 4 estudos em animais para compor este estudo. Em todas essas pesquisas apresentadas, a presença de células-tronco foi capaz de melhorar parâmetros clínicos, histológicos e morfológicos da articulação temporomandibular.

CONCLUSÃO: O uso de células-tronco parece ser eficaz no tratamento das alterações degenerativas das estruturas associadas à articulação temporomandibular. Todavia, devido ao reduzido número de estudos e sua heterogeneidade, os resultados apresentados devem ser avaliados com parcimônia.

Palavras-chave

Células-tronco, Disco da articulação temporomandibular, Transtornos da articulação temporomandibular

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Submitted date:
04/12/2020

Accepted date:
06/01/2020

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