Brazilian Journal of Pain
https://brjp.org.br/article/doi/10.5935/2595-0118.20200044
Brazilian Journal of Pain
Review Article

Effect of mesenchymal stem cells on the regeneration of structures associated with temporomandibular joint: narrative review

Efeito de células-tronco mesenquimais na regeneração das estruturas associadas à articulação temporomandibular: revisão narrativa

Caren Serra Bavaresco; Thiago Kreutz Grossmann; Daniela Seitenfus Rehm; Eduardo Grossmann

http://dx.doi.org/10.5935/2595-0118.20200044 BrJP, vol.3, n3, p.275-279, 2020
PDF English
PDF Português
SciELO
Downloads: 0
Views: 381

Abstract

BACKGROUND AND OBJECTIVES: Temporomandibular disorders are the problems involving the masticatory muscles and/or the temporomandibular joint and, among them, the bone and joint disc degenerative processes stand out. However, an effective treatment for these cases has not yet been identified in the literature. Thus, the primary objective of this study was to evaluate the reparative potential of mesenchymal stem cells on degenerative changes in structures associated with the temporomandibular joint in humans and animal models.

CONTENTS: This narrative review included intervention trials in humans and animals that presented as an outcome variable the repair of joint discs and/or temporomandibular joint. The following databases were used: Pubmed, LILACS, Scielo and Google Scholar. Titles and abstracts were analyzed for the pre-selection of articles potentially eligible for inclusion in this review. The information collected from each article was included in a specific spreadsheet for this purpose containing the year of publication, article title, author’s name, study location, type of study, methodology, results, and conclusions. Two human studies and four animal studies were selected to compose the narrative review. In all studies presented, the presence of stem cells was able to improve the clinical, histological, and morphological parameters of the temporomandibular joint.

CONCLUSION: The use of stem cells seems to be effective in treating degenerative changes in temporomandibular joint associated structures in both animal and human models. However, due to the small number of studies and their heterogeneity, the results presented should be evaluated sparingly.

Keywords

Stem cells, Temporomandibular joint disc, Temporomandibular joint disorders

Resumo

JUSTIFICATIVA E OBJETIVOS: As desordens temporomandibulares constituem-se em um termo coletivo de problemas que envolvem os músculos mastigatórios e/ou a articulação temporomandibular. Dentre esses, destacam-se os processos degenerativos ósseos e do disco articular, contudo, ainda não foi identificado na literatura um tratamento eficaz para esses casos. Dessa forma, o objetivo desse estudo foi avaliar o potencial reparador das células-tronco mesenquimais sobre as alterações degenerativas das estruturas associadas à articulação temporomandibular em humanos e em modelos animais.

CONTEÚDO: Foram incluídos ensaios de intervenção em humanos e em animais que apresentassem como variável desfecho o reparo dos discos articulares e/ou da articulação temporomandibular. Foram realizadas buscas nas seguintes bases de dados: Pubmed, LILACS, Scielo e Google Acadêmico. Os títulos e resumos foram analisados para a pré-seleção dos artigos potencialmente elegíveis para sua inclusão. As informações coletadas de cada artigo foram incluídas em planilha específica para essa finalidade contendo o ano de publicação, título do artigo, nome do autor, local do estudo, tipo de estudo, metodologia, resultado e conclusões. Foram selecionados 2 estudos em humanos e 4 estudos em animais para compor este estudo. Em todas essas pesquisas apresentadas, a presença de células-tronco foi capaz de melhorar parâmetros clínicos, histológicos e morfológicos da articulação temporomandibular.

CONCLUSÃO: O uso de células-tronco parece ser eficaz no tratamento das alterações degenerativas das estruturas associadas à articulação temporomandibular. Todavia, devido ao reduzido número de estudos e sua heterogeneidade, os resultados apresentados devem ser avaliados com parcimônia.

Palavras-chave

Células-tronco, Disco da articulação temporomandibular, Transtornos da articulação temporomandibular

References

Okeson JP, de Leeuw R. Differential diagnosis of temporomandibular disorders and other orofacial pain disorders. Dent Clin North Am. 2011;55(1):105-20.

Ohrbach R, Dworkin SF. The evolution of TMD diagnosis: past, present, future. J Dent Res. 2016;95(10):1093-101.

Kellesarian SV, Al-Kheraif AA, Vohra F, Ghanem A, Malmstrom H, Romanos GE. Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: a systematic review. Cytokine. 2016;77:98-106.

Grossmann E. Algias Craniofaciais: Diagnóstico e Tratamento. 2019.

Willard VP, Kalpakci KN, Reimer AJ, Athanasiou KA. The regional contribution of glycosaminoglycans to temporomandibular joint disc compressive properties. J Biomech Eng. 2012;134(1):1-8.

Fazaeli S, Ghazanfari S, Everts V, Smit TH, Koolstra JH. The contribution of collagen fibers to the mechanical compressive properties of the temporomandibular joint disc. Osteoarthritis Cartilage. 2016;24(7):1292-301.

Mäenpää K, Ellä V, Mauno J, Kellomäki M, Suuronen R, Ylikomi T. Use of adipose stem cells and polylactide discs for tissue engineering of the temporomandibular joint disc. J R Soc Interface. 2010;7(42):177-88.

Colombo V, Palla S, Gallo LM. Temporomandibular joint loading patterns related to joint morphology: a theoretical study. Cells Tissues Organs. 2008;187(4):295-306.

Wang XD, Cui SJ, Liu Y, Luo Q, Du RJ, Kou XX. Deterioration of mechanical properties of discs in chronically inflamed TMJ. J Dent Res. 2014;93(11):1170-6.

Wang XD, Kou XX, Mao JJ, Gan YH, Zhou YH. Sustained inflammation induces degeneration of the temporomandibular joint. J Dent Res. 2012;91(5):499-505.

Farrar WB. Characteristics of the condylar path in internal derangements of the TMJ. J Prosthet Dent. 1978;39(3):319-23.

Saleh R, Reza HM. Short review on human umbilical cord lining epithelial cells and their potential clinical applications. Stem Cell Res Ther. 2017;8(1):222.

Huh Y, Ji RR, Chen G. Neuroinflammation, bone marrow stem cells, and chronic pain. Front Immunol. 2017;8:1014.

de Souza Tesch R, Takamori ER, Menezes K, Carias RBV, Dutra CLM, de Freitas Aguiar M. Temporomandibular joint regeneration: proposal of a novel treatment for condylar resorption after orthognathic surgery using transplantation of autologous nasal septum chondrocytes, and the first human case report. Stem Cell Res Ther. 2018;9(1):94.

Carboni A, Amodeo G, Perugini M, Arangio P, Orsini R, Scopelliti D. Temporomandibular disorders clinical and anatomical outcomes after fat-derived stem cells injection. J Craniofac Surg. 2019;30(3):793-7.

Ahtiainen K, Mauno J, Ellä V, Hagström J, Lindqvist C, Miettinen S. Autologous adipose stem cells and polylactide discs in the replacement of the rabbit temporomandibular joint disc. J R Soc Interface. 2013;10(85):20130287.

Ciocca L, Donati D, Ragazzini S, Dozza B, Rossi F, Fantini M. Mesenchymal stem cells and platelet gel improve bone deposition within CAD-CAM custom-made ceramic HA scaffolds for condyle substitution. Biomed Res Int. 2013;2013:549762.

Zhang M, Yang H, Lu L, Wan X, Zhang J, Zhang H. Matrix replenishing by BMSCs is beneficial for osteoarthritic temporomandibular joint cartilage. Osteoarthritis Cartilage. 2017;25(9):1551-62.

Zaki AA, Zaghloul M, Helal ME, Mansour NA, Grawish ME. Impact of autologous bone marrow-derived stem cells on degenerative changes of articulating surfaces associated with the arthritic temporomandibular joint: an experimental study in Rabbits. J Oral Maxillofac Surg. 2017;75(12):2529-39.

Nejadnik H, Hui JH, Feng Choong EP, Tai BC, Lee EH. Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am J Sports Med. 2010;38(6):1110-6.

Kanafi MM, Ramesh A, Gupta PK, Bhonde RR. Dental pulp stem cells immobilized in alginate microspheres for applications in bone tissue engineering. Int Endod J. 2014;47(7):687-97.

Salash JR, Hossameldin RH, Almarza AJ, Chou JC, McCain JP, Mercuri LG. Potential indications for tissue engineering in temporomandibular joint surgery. J Oral Maxillofac Surg. 2016;74(4):705-11.

Helgeland E, Shanbhag S, Pedersen TO, Mustafa K, Rosén A. Scaffold-based temporomandibular joint tissue regeneration in experimental animal models: a systematic review Tissue Eng Part. B Rev. 2018;24(4):300-16.

Zhang M, Yang H, Lu L, Wan X, Zhang J, Zhang H. Matrix replenishing by BMSCs is beneficial for osteoarthritic temporomandibular joint cartilage. Osteoarthritis Cartilage. 2017;25(9):1551-62.

Zhou Y, Wang T, Hamilton JL, Chen D. Wnt/?-catenin signaling in osteoarthritis and in other forms of arthritis. Curr Rheumatol Rep. 2017;19(9):53.

Chen G, Park CK, Xie RG, Ji RR. Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-? secretion. J Clin Invest. 2015;125(8):3226-40.

Di Cesare Mannelli L, Tenci B, Micheli L, Vona A, Corti F, Zanardelli M. Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: role of VEGF-A modulation. Neuropharmacology. 2018;131:166-75.

Submitted date:
04/12/2020

Accepted date:
06/01/2020

5f6a5a150e8825e40c9fefcb brjp Articles
2595-3192 (Electronic) 2595-0118 (Printed)
BrJP ©2024 All rights reserved.

BrJP

Share this page
Page Sections